CD40 (mouse) monoclonal antibody (FGK45) (preservative free) | Enzo Life Sciences ALX-805-046PF-C500 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CD40 (mouse) monoclonal antibody (FGK45) (preservative free)

catalog :

ALX-805-046PF-C500

quantity :

500 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

FGK45

reactivity :

mouse

application :

immunocytochemistry, flow cytometry, blocking or activating experiments

more info or order :

Enzo Life Sciences product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; 0.5 ug/ml	Zanotti K, Maul R, Castiblanco D, Yang W, Choi Y, Fox J, et al. ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol. 2015;194:35-42 pubmed publisher
immunocytochemistry; mouse	Coffey F, Manser T. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010;184:4871-9 pubmed publisher
	Avery D, Kane A, Nguyen T, Lau A, Nguyen A, Lenthall H, et al. Germline-activating mutations in PIK3CD compromise B cell development and function. J Exp Med. 2018;215:2073-2095 pubmed publisher
	Goldman N, Valiuskyte K, Londregan J, Swider A, Somerville J, Riggs J. Macrophage regulation of B cell proliferation. Cell Immunol. 2017;314:54-62 pubmed publisher
	Lee Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, et al. Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. J Immunol. 2016;196:3385-97 pubmed publisher
	Shigeta A, Tada Y, Wang J, Ishizaki S, Tsuyusaki J, Yamauchi K, et al. CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. Am J Physiol Lung Cell Mol Physiol. 2012;303:L141-51 pubmed publisher
	Fear V, Burchell J, Lai S, Wikstrom M, Blank F, von Garnier C, et al. Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance. J Immunol. 2011;187:4561-70 pubmed publisher
	Yanai H, Chiba S, Ban T, Nakaima Y, Onoe T, Honda K, et al. Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs). Proc Natl Acad Sci U S A. 2011;108:11542-7 pubmed publisher
	Carlucci F, Fossati Jimack L, Dumitriu I, Heidari Y, Walport M, Szajna M, et al. Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol. 2010;184:6256-65 pubmed publisher
	Schroder W, Le T, Major L, Street S, Gardner J, Lambley E, et al. A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity. J Immunol. 2010;184:2663-70 pubmed publisher
	Zhang T, Al Alwan M, Marshall A. The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression. J Immunol. 2010;184:164-72 pubmed publisher
	Zhang H, Rosenberg S, Coffey F, He Y, Manser T, Hardy R, et al. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009;182:207-15 pubmed
	Bartholdy C, Kauffmann S, Christensen J, Thomsen A. Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus. J Immunol. 2007;178:1662-70 pubmed

product information

Product ID :

ALX-805-046PF

Catalog Number :

ALX-805-046PF-C500

Product Name :

CD40 (mouse) monoclonal antibody (FGK45) (preservative free)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

500 µg

list of Pubmed id :

25404367, 22610351, 21930961, 21709231, 20435933, 20335528, 20130210, 19949096, 19109151, 17237416

Clone :

FGK45

Isotype :

IgG2a

Product Description :

Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

SPECIES REACTIVITY :

Mouse

ALTnames :

TNFRSF 5

Immunogen :

Recombinant mouse CD40 fusion protein.

Buffer :

Liquid. In sterile PBS.

Uses :

Functional Application: activates B and NK cells in vivo and in vitro.

Application Summary :

FC, FUNC

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage