CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate) | Enzo Life Sciences ALX-805-046B-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

catalog :

ALX-805-046B-C050

quantity :

50 µg

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

FGK45

The same clone is also sold as:

Abnova: MAB16103, MAB16102

reactivity :

mouse

application :

flow cytometry

citations: 13

Reference
Lee Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, et al. Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. J Immunol. 2016;196:3385-97 pubmed publisher
Zanotti K, Maul R, Castiblanco D, Yang W, Choi Y, Fox J, et al. ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol. 2015;194:35-42 pubmed publisher
Coffey F, Manser T. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010;184:4871-9 pubmed publisher
Bartholdy C, Kauffmann S, Christensen J, Thomsen A. Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus. J Immunol. 2007;178:1662-70 pubmed
Hellings P, Kasran A, Bullens D, Overbergh L, Mathieu C, Heremans H, et al. IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling. J Immunol. 2006;177:5138-44 pubmed
Greene J, DeVecchio J, Gould M, Auletta J, Heinzel F. In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN. J Immunol. 2006;176:5995-6003 pubmed
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005;434:772-7 pubmed
Erlebacher A, Zhang D, Parlow A, Glimcher L. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest. 2004;114:39-48 pubmed
McGregor C, Schoenberger S, Green E. CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes. Proc Natl Acad Sci U S A. 2004;101:9345-50 pubmed
Turner J, Rakhmilevich A, Burdelya L, Neal Z, Imboden M, Sondel P, et al. Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells. J Immunol. 2001;166:89-94 pubmed
Mauri C, Mars L, Londei M. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med. 2000;6:673-9 pubmed
Rolink A, Andersson J, Melchers F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur J Immunol. 1998;28:3738-48 pubmed
Rolink A, Melchers F, Andersson J. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity. 1996;5:319-30 pubmed

product information

Product ID :

ALX-805-046B

Catalog Number :

ALX-805-046B-C050

Product Name :

CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

Host species :

Rat

Clonality :

Monoclonal

Conjugation :

Biotin

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

17237416, 17015698, 16670308, 15800576, 15232610, 15192149, 11123280, 10835684, 9842916, 8885865

Clone :

FGK45

Isotype :

IgG2a

Product Description :

Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

SPECIES REACTIVITY :

Mouse

ALTnames :

TNFRSF 5

Immunogen :

Recombinant mouse CD40 fusion protein.

Buffer :

Liquid. In sterile PBS.

Application Summary :

Storage :

+4°C