Fas (human) monoclonal antibody (APO-1-1) | Enzo Life Sciences ALX-805-022-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Fas (human) monoclonal antibody (APO-1-1)

catalog :

ALX-805-022-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

APO-1-1

The same clone is also sold as:

Invitrogen: BMS151, BMS151FI

reactivity :

human

application :

immunohistochemistry, flow cytometry

citations: 6

Reference
Backes C, Friedmann K, Mang S, Knörck A, Hoth M, Kummerow C. Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms. J Biol Chem. 2018;293:16348-16363 pubmed publisher
Salva K, Kim Y, Rahbar Z, Wood G. Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma. Photochem Photobiol. 2018;94:1058-1065 pubmed publisher
Ramaswamy M, Cruz A, Cleland S, Deng M, Price S, Rao V, et al. Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains. Cell Death Differ. 2011;18:712-20 pubmed publisher
Wajant H, Haas E, Schwenzer R, Muhlenbeck F, Kreuz S, Schubert G, et al. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD). J Biol Chem. 2000;275:24357-66 pubmed
Huang D, Hahne M, Schroeter M, Frei K, Fontana A, Villunger A, et al. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). Proc Natl Acad Sci U S A. 1999;96:14871-6 pubmed
Leithäuser F, Dhein J, Mechtersheimer G, Koretz K, Bruderlein S, Henne C, et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest. 1993;69:415-29 pubmed

product information

Product ID :

ALX-805-022

Catalog Number :

ALX-805-022-C100

Product Name :

Fas (human) monoclonal antibody (APO-1-1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

10823821, 10611305, 7693996

Clone :

APO-1-1

Isotype :

IgG1

SPECIES REACTIVITY :

Human

ALTnames :

CD95, APO-1, TNFRSF 6

Immunogen :

Human Fas (CD95; APO-1).

Buffer :

Liquid. In PBS, pH 7.2-7.4.

Uses :

APO-1-1 (IgG1) is an isotype-switch variant of the original clone APO-1-3 (ALX-805-020). Since undesired side reactions in immunohistochemistry are minimal for IgG1 antibodies, APO-1-1 is especially useful for immunohistology on cryostat sections and on cytospin preparations. Not suitable for stainings on paraffin sections. Functional Application: Induces apoptosis upon cross-linking.

Application Summary :

FC, IHC (FS), FUNC

Storage :

+4°C