FLIP (human) monoclonal antibody (7F10) | Enzo Life Sciences ALX-804-961-0100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

FLIP (human) monoclonal antibody (7F10)

catalog :

ALX-804-961-0100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7F10

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 7a	Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNÎ³ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
western blot; human; fig 3a	Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
western blot; human; loading ...; fig 4.d,e,f	Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
western blot; human; fig 2	Huang Y, Yang X, Xu T, Kong Q, Zhang Y, Shen Y, et al. Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs. Int J Oncol. 2016;49:153-63 pubmed publisher
western blot; human; loading ...; fig 5	Waguia Kontchou C, Tzivelekidis T, Gentle I, Hacker G. Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact. Cell Microbiol. 2016;18:1583-1595 pubmed publisher
western blot; human; fig 5	Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed publisher
western blot; human; fig 3	Han M, Lee D, Woo S, Seo B, Min K, Kim S, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep. 2016;6:18642 pubmed publisher
western blot; human	Shi S, Wang Q, Xu J, Jang J, Padilla M, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget. 2015;6:1640-51 pubmed
western blot; human; fig 2	MorlÃ© A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisher
western blot; human; 1:1000	Han M, Woo S, Min K, Kim S, Park J, Kim D, et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression. Chem Biol Interact. 2015;228:69-78 pubmed publisher
	Kim J, Kim M, Choi K, Son J. Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover. Int J Biochem Cell Biol. 2016;78:327-334 pubmed publisher
	Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, et al. Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Clin Cancer Res. 2016;22:1138-49 pubmed publisher
	Xu J, Xu X, Shi S, Wang Q, Saxton B, He W, et al. Autophagy-Mediated Degradation of IAPs and c-FLIP(L) Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24. J Cell Biochem. 2016;117:1136-44 pubmed publisher
	Cencioni M, Santini S, Ruocco G, Borsellino G, De Bardi M, Grasso M, et al. FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients. Cell Death Dis. 2015;6:e1741 pubmed publisher
	Lin W, Tsai H, Liao H, Tang C, Wu Y, Hsu P, et al. Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP. Cell Death Dis. 2014;5:e1109 pubmed publisher

product information

Product ID :

ALX-804-961

Catalog Number :

ALX-804-961-0100

Product Name :

FLIP (human) monoclonal antibody (7F10)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

25950471, 25619640, 24603337

Clone :

7F10

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with the adapter protein, FADD, and caspase-8 and –10, and potently inhibits apoptosis induced by death receptors CD95, DR3, TRAIL-R and TNFR1.

ALTnames :

CASPER, CLARP, I-FLICE, Usurpin, CFLAR

Immunogen :

Recombinant human FLIP.

Buffer :

Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Application Summary :

ELISA, FC, IHC, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage