AIM2 (human) monoclonal antibody (3B10) | Enzo Life Sciences ALX-804-891-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

AIM2 (human) monoclonal antibody (3B10)

catalog :

ALX-804-891-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B10

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Reference
Fernandes Alnemri T, Yu J, Datta P, Wu J, Alnemri E. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009;458:509-13 pubmed publisher
Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher
Cresswell K, Clarke C, Jackson J, Darcy P, Trapani J, Johnstone R. Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun. 2005;326:417-24 pubmed

product information

Product ID :

ALX-804-891

Catalog Number :

ALX-804-891-C100

Product Name :

AIM2 (human) monoclonal antibody (3B10)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

19158676, 19158675, 15582594

Clone :

3B10

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. It has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms an inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1β.

ALTnames :

Interferon-inducible protein AIM2, Absent in melanoma 2

Immunogen :

Recombinant human AIM2 (aa 1-186) with GST-tag.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.

Uses :

Detects a band of ~39kDa by Western blot.

Application Summary :

IF, IP, WB