product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
LRRC32 monoclonal antibody (Plato-1) (FITC conjugate)
catalog :
ALX-804-867FI-0100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
Plato-1
reactivity :
human, mouse
application :
flow cytometry
more info or order :
Enzo Life Sciences product webpage
citations: 11
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2g
Zhang M, Pan X, Fujiwara K, Jurcak N, Muth S, Zhou J, et al. Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism. Signal Transduct Target Ther. 2021;6:366 pubmed publisher
Hahn S, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, et al. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016;7:42996-43009 pubmed publisher
Zhang L, Reckling S, Dean G. Phenotypic and functional analysis of CD1a+ dendritic cells from cats chronically infected with feline immunodeficiency virus. Comp Immunol Microbiol Infect Dis. 2015;42:53-9 pubmed publisher
Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie P, et al. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. J Biol Chem. 2015;290:20105-16 pubmed publisher
Carrillo Galvez A, Cobo M, Cuevas Ocaña S, Gutiérrez Guerrero A, Sánchez Gilabert A, Bongarzone P, et al. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells. 2015;33:183-95 pubmed publisher
Miller M, Fogle J, Ross P, Tompkins M. Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency. AIDS Res Hum Retroviruses. 2013;29:641-51 pubmed publisher
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum C, Chougnet C. Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy. PLoS ONE. 2011;6:e28118 pubmed publisher
Chan D, Somani A, Young A, Massari J, Ohtola J, Sugiyama H, et al. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32). BMC Biochem. 2011;12:27 pubmed publisher
Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 2009;106:13439-44 pubmed publisher
Tran D, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach E. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 2009;106:13445-50 pubmed publisher
Tran D, Shevach E. Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells. Hum Immunol. 2009;70:294-9 pubmed publisher
product information
Product ID :
ALX-804-867FI
Catalog Number :
ALX-804-867FI-0100
Product Name :
LRRC32 monoclonal antibody (Plato-1) (FITC conjugate)
Host species :
Mouse
Clonality :
Monoclonal
Conjugation :
FITC
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
23373523, 22162758, 21615933, 19666573, 19651619, 19236900
Clone :
Plato-1
Isotype :
IgG2b
SPECIES REACTIVITY :
Human, Mouse
Background :
LRRC32 (leucine rich repeat containing 32; also known as GARP or Garpin; Glycoprotein A repetitions predominant) is a glycoprotein expressed on the cell surface of megakaryocytes, platelets and activated regulatory T (Treg) cells.
ALTnames :
Leucine-rich repeat-containing protein 32, GARP, Garpin, Glycoprotein A repetitions predominant
Immunogen :
Recombinant human LRRC32 (aa 20-627).
Buffer :
Liquid. In PBS containing 0.09% sodium azide.
Uses :
Detects a band of ~100kDa by Western blot. Calculated molecular weight of the full-length protein is ~72kDa.
Application Summary :
FC
Storage :
+4°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.