MDA5 (human) monoclonal antibody (Hely-1) | Enzo Life Sciences ALX-804-863-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

MDA5 (human) monoclonal antibody (Hely-1)

catalog :

ALX-804-863-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Hely-1

The same clone is also sold as:

Abnova: MAB16090

reactivity :

human

application :

western blot, ELISA, immunoprecipitation

product information

Product ID :

ALX-804-863

Catalog Number :

ALX-804-863-C100

Product Name :

MDA5 (human) monoclonal antibody (Hely-1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

Clone :

Hely-1

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses.

ALTnames :

Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2

Immunogen :

Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).

Buffer :

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Uses :

ELISA. Immunoprecipitation (1:100). Western Blot (1:1'000)

Application Summary :

ELISA, IP, WB

Storage :

-20°C