NLRP3/NALP3 (human) monoclonal antibody (Nalpy3-b) | Enzo Life Sciences ALX-804-819-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

NLRP3/NALP3 (human) monoclonal antibody (Nalpy3-b)

catalog :

ALX-804-819-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Nalpy3-b

The same clone is also sold as:

Novus Biologicals: NBP1-97601
Invitrogen: MA1-25943
Abnova: MAB16140, MAB3724

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Enzo Life Sciences product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 5a	Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
western blot; human; fig 1	Choulaki C, Papadaki G, Repa A, Kampouraki E, Kambas K, Ritis K, et al. Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis. Arthritis Res Ther. 2015;17:257 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100 immunocytochemistry; human; 1:100 western blot; human; 1:1000	Tseng W, Thein T, Kinnunen K, Lashkari K, Gregory M, D Amore P, et al. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013;54:110-20 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	de Koning H, Rodijk Olthuis D, van Vlijmen Willems I, Joosten L, Netea M, Schalkwijk J, et al. A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis. J Invest Dermatol. 2010;130:2611-20 pubmed publisher
western blot; human	Mayor A, Martinon F, De Smedt T, Petrilli V, Tschopp J. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 2007;8:497-503 pubmed
	Wu Y, Lai M. Measuring NLR Oligomerization V: In Situ Proximity Ligation Assay. Methods Mol Biol. 2016;1417:185-95 pubmed publisher
	Repa A, Bertsias G, Petraki E, Choulaki C, Vassou D, Kambas K, et al. Dysregulated production of interleukin-1Î² upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever. Hum Immunol. 2015;76:488-95 pubmed publisher
	McGilligan V, Gregory Ksander M, Li D, Moore J, Hodges R, Gilmore M, et al. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS ONE. 2013;8:e74010 pubmed publisher
	Benoit M, Clarke E, Morgado P, Fraser D, Tenner A. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 2012;188:5682-93 pubmed publisher
	Shio M, Tiemi Shio M, Eisenbarth S, Savaria M, Vinet A, Bellemare M, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009;5:e1000559 pubmed publisher
	Lev Sagie A, Prus D, Linhares I, Lavy Y, Ledger W, Witkin S. Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol. 2009;200:303.e1-6 pubmed publisher
	Kummer J, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem. 2007;55:443-52 pubmed
	Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed

product information

Product ID :

ALX-804-819

Catalog Number :

ALX-804-819-C100

Product Name :

NLRP3/NALP3 (human) monoclonal antibody (Nalpy3-b)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

26642243, 26074413, 24040145, 23221073, 22523386, 19696895, 19254587, 17164409, 15030775

Clone :

Nalpy3-b

Isotype :

IgG1

SPECIES REACTIVITY :

Human

ALTnames :

NACHT-, LRR- and PYD-containing protein 3, CIAS1, Cryopyrin, Cold autoinflammatory syndrome 1 protein, PYPAF1, PYRIN-containing APAF1-like protein 1

Immunogen :

Recombinant human NLRP3/NALP3 (NACHT-, LRR- and PYD-containing protein 3) (pyrin domain).

Specificity :

Detects endogenous protein by IP and WB.

Buffer :

Liquid. In PBS containing 0.02% sodium azide.

Application Summary :

IHC (FS), IP, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage