BAP31 monoclonal antibody (CC-1) | Enzo Life Sciences ALX-804-812-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

BAP31 monoclonal antibody (CC-1)

catalog :

ALX-804-812-C100

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

CC-1

The same clone is also sold as:

Santa Cruz Biotechnology: sc-56007
Invitrogen: MA3-002

reactivity :

human, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Enzo Life Sciences product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human	Heinz L, Rebsamen M, Rossi D, Staehli F, Schroder K, Quadroni M, et al. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death Differ. 2012;19:722-31 pubmed publisher
	Walker W, Oehler A, Edinger A, Wagner K, Gunn T. Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biol Cell. 2016;108:324-337 pubmed publisher
	Ladasky J, Boyle S, Seth M, Li H, Pentcheva T, Abe F, et al. Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules. J Immunol. 2006;177:6172-81 pubmed
	Zen K, Utech M, Liu Y, Soto I, Nusrat A, Parkos C. Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. J Biol Chem. 2004;279:44924-30 pubmed
	Manley H, Lennon V. Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells. J Histochem Cytochem. 2001;49:1235-43 pubmed

product information

Product ID :

ALX-804-812

Catalog Number :

ALX-804-812-C100

Product Name :

BAP31 monoclonal antibody (CC-1)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

17056546, 15294914, 11561007

Clone :

CC-1

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Primate, Hamster, Bovine

Background :

BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.

ALTnames :

DXS1357E, B cell receptor-associated protein BAP31, BCR-associated protein BAP31, p28 BAP31, CDM protein, 6C6-AG tumor-associated antigen, BCAP31

Immunogen :

Solubilized membranes of the IMR-32 human neuroblastoma cell line.

Specificity :

Recognizes an epitope (aa 230-246) encompassing a caspase recognition site and the ER-homing motif (KKEE), present at the C-terminus of human, primate, bovine and hamster BAP31.

Buffer :

Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.

Uses :

Works on endogenous in ICC, IHC and WB.

Application Summary :

ELISA, ICC, IHC (FS), IP, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage