LAG-3 (human) monoclonal antibody (11E3) | Enzo Life Sciences ALX-804-805-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

LAG-3 (human) monoclonal antibody (11E3)

catalog :

ALX-804-805-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11E3

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 4

Reference
Juno J, Stalker A, Waruk J, Oyugi J, Kimani M, Plummer F, et al. Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment. Retrovirology. 2015;12:17 pubmed publisher
Triebel F, Hacene K, Pichon M. A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. Cancer Lett. 2006;235:147-53 pubmed
Huard B, Mastrangeli R, Prigent P, Bruniquel D, Donini S, el Tayar N, et al. Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. Proc Natl Acad Sci U S A. 1997;94:5744-9 pubmed
Huard B, Gaulard P, Faure F, Hercend T, Triebel F. Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. Immunogenetics. 1994;39:213-7 pubmed

product information

Product ID :

ALX-804-805

Catalog Number :

ALX-804-805-C100

Product Name :

LAG-3 (human) monoclonal antibody (11E3)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

25810006, 15946792, 9159144, 7506235

Clone :

11E3

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Monkey

Background :

The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

ALTnames :

Lymphocyte activation gene-3, FDC protein, CD223

Immunogen :

Recombinant human LAG-3 (lymphocyte activation gene-3).

Specificity :

Recognizes the first N-terminal D1 domain of LAG-3.

Buffer :

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Application Summary :

ELISA, ICC, IHC (FS), IP, WB, FUNC

Storage :

-20°C