Trop-2 (human) monoclonal antibody (MOv16) | Enzo Life Sciences ALX-804-650-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Trop-2 (human) monoclonal antibody (MOv16)

catalog :

ALX-804-650-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MOv16

reactivity :

hamsters, human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Enzo Life Sciences product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; hamsters; loading ...; fig 3d	Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa Ando T, et al. Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope. Biochem Biophys Res Commun. 2015;458:877-82 pubmed publisher
immunohistochemistry - paraffin section; human western blot; human	Stepan L, Trueblood E, Hale K, Babcook J, Borges L, Sutherland C. Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target. J Histochem Cytochem. 2011;59:701-10 pubmed publisher
	Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M. Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res. 2006;12:3057-63 pubmed
	Santin A, Zhan F, Bellone S, Palmieri M, Cane S, Bignotti E, et al. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Int J Cancer. 2004;112:14-25 pubmed
	Gerritsen M, Soriano R, Yang S, Ingle G, Zlot C, Toy K, et al. In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set. Physiol Genomics. 2002;10:13-20 pubmed
	Pelosi G, Pasini F, Pavanel F, Bresaola E, Schiavon I, Iannucci A. Effects of different immunolabeling techniques on the detection of small-cell lung cancer cells in bone marrow. J Histochem Cytochem. 1999;47:1075-88 pubmed
	Ripani E, Sacchetti A, Corda D, Alberti S. Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 1998;76:671-6 pubmed
	Schön M, Orfanos C. Transformation of human keratinocytes is characterized by quantitative and qualitative alterations of the T-16 antigen (Trop-2, MOv-16). Int J Cancer. 1995;60:88-92 pubmed
	Lipinski M, Parks D, Rouse R, Herzenberg L. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci U S A. 1981;78:5147-50 pubmed
	Miotti S, Canevari S, Menard S, Mezzanzanica D, Porro G, Pupa S, et al. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Int J Cancer. 1987;39:297-303 pubmed
	Alberti S, Miotti S, Stella M, Klein C, Fornaro M, Menard S, et al. Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2. Hybridoma. 1992;11:539-45 pubmed

product information

Product ID :

ALX-804-650

Catalog Number :

ALX-804-650-C100

Product Name :

Trop-2 (human) monoclonal antibody (MOv16)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

25701778, 16707602, 15305371, 12118101, 10424892, 9610724, 7814156, 7029529, 2434438, 1459581

Clone :

MOv16

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells. Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis. Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.

ALTnames :

Tumor-associated calcium signal transducer 2, TACSTD2, GA733-1

Immunogen :

Membrane preparation from human ovarian carcinoma containing human Trop-2 (tumor-associated calcium signal transducer 2).

Buffer :

Liquid. In 10mM sodium phosphate buffer, pH 7.4, containing 150mM sodium chloride.

Application Summary :

FC, ICC, IHC (FS), IP, WB

Storage :

+4°C

more info or order :

Enzo Life Sciences product webpage