c-Myc (human) monoclonal antibody (4H3) | Enzo Life Sciences ALX-804-627-L001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

c-Myc (human) monoclonal antibody (4H3)

catalog :

ALX-804-627-L001

quantity :

1 ml

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

4H3

reactivity :

human, zebrafish

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Sommer A, Bousset K, Kremmer E, Austen M, Luscher B. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. J Biol Chem. 1998;273:6632-42 pubmed

product information

Product ID :

ALX-804-627

Catalog Number :

ALX-804-627-L001

Product Name :

c-Myc (human) monoclonal antibody (4H3)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

1 ml

list of Pubmed id :

9506959

Clone :

4H3

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Zebrafish

Background :

Myc proteins are important regulators of cell behaviour and work as transcription factors that belong to the basic region/helix-loop-helix/leucine zipper family of DNA binding proteins. To regulate its target genes, Myc recruits several different cofactors (e.g. PARP-10). They control a variety of cellular functions including protein synthesis, cell cycle progression, and apoptosis, thereby modulating cell growth and proliferation, differentiation, and survivial of cells. The family of myc genes includes B-myc, L-myc, N-myc and s-myc; however only c-myc, L-myc and N-myc have neoplastic potential. The c-Myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene. It is a proto-oncogene, whereas the deregulated expression of c-Myc is observed in the majority of human and animal tumors often with poor prognosis. The proto-oncogene c-Myc is implicated in various physiological processes; cell growth, proliferation, loss of differentiation and cell death (apoptosis). It also has been implicated in the loss and dysfunction of insulin-producing beta cells in diabetes. Studies in mice suggest that c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells. c-Myc activity is normally tightly controlled by external signals including growth factors, mitogens and β-catenin which promote, and factors as TGF-beta which inhibit.

ALTnames :

Myc proto-oncogene, Transcription factor p64

Immunogen :

Recombinant human c-Myc (aa 1-262).

Buffer :

Liquid. Tissue culture supernatant (TCS) containing 0.1% sodium azide.

Application Summary :

ICC, IP, WB

Storage :

+4°C