BAP31 monoclonal antibody (A1/182) | Enzo Life Sciences ALX-804-601-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

BAP31 monoclonal antibody (A1/182)

catalog :

ALX-804-601-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A1/182

The same clone is also sold as:

Abnova: MAB5149

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 8

Reference
Chadrin A, Hess B, San Roman M, Gatti X, Lombard B, Loew D, et al. Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J Cell Biol. 2010;189:795-811 pubmed publisher
Bonnon C, Wendeler M, Paccaud J, Hauri H. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. J Cell Sci. 2010;123:1705-15 pubmed publisher
Mitrovic S, Ben Tekaya H, Koegler E, Gruenberg J, Hauri H. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mol Biol Cell. 2008;19:1976-90 pubmed publisher
Nyfeler B, Michnick S, Hauri H. Capturing protein interactions in the secretory pathway of living cells. Proc Natl Acad Sci U S A. 2005;102:6350-5 pubmed
Breuza L, Halbeisen R, Jeno P, Otte S, Barlowe C, Hong W, et al. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. J Biol Chem. 2004;279:47242-53 pubmed
Klopfenstein D, Klumperman J, Lustig A, Kammerer R, Oorschot V, Hauri H. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. J Cell Biol. 2001;153:1287-300 pubmed
Klopfenstein D, Kappeler F, Hauri H. A novel direct interaction of endoplasmic reticulum with microtubules. EMBO J. 1998;17:6168-77 pubmed
Klumperman J, Schweizer A, Clausen H, Tang B, Hong W, Oorschot V, et al. The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment. J Cell Sci. 1998;111 ( Pt 22):3411-25 pubmed

product information

Product ID :

ALX-804-601

Catalog Number :

ALX-804-601-C100

Product Name :

BAP31 monoclonal antibody (A1/182)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

20498018, 20427317, 18287528, 15849265, 15308636, 11402071, 9799226, 9788882

Clone :

A1/182

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Monkey

Background :

BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.

ALTnames :

p28 BAP31, B cell receptor-associated protein BAP31, BCR-associated protein BAP31, CDM, DXS1357E, 6C6-AG tumor-associated antigen, BCAP31

Immunogen :

BAP31 (BCR associated protein BAP031) from Vero monkey cells.

Buffer :

Lyophilized. Protein G-affinity purified and gel filtrated (FPLC).

Application Summary :

ELISA, FC, ICC, IHC (FS), IP, WB

Storage :

-20°C