c-erbB-2 (human) monoclonal antibody (MGR2) | Enzo Life Sciences ALX-804-573-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

c-erbB-2 (human) monoclonal antibody (MGR2)

catalog :

ALX-804-573-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MGR2

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 2b	Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed publisher
	Leoni V, Gatta V, Palladini A, Nicoletti G, Ranieri D, Dall Ora M, et al. Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases. Oncotarget. 2015;6:34774-87 pubmed publisher
	Tamborini E, Virdis E, Negri T, Orsenigo M, Brich S, Conca E, et al. Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas. Neuro Oncol. 2010;12:776-89 pubmed publisher
	Magnifico A, Albano L, Campaner S, Delia D, Castiglioni F, Gasparini P, et al. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin Cancer Res. 2009;15:2010-21 pubmed publisher
	Pupa S, Iezzi M, Di Carlo E, Invernizzi A, Cavallo F, Meazza R, et al. Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination. Cancer Res. 2005;65:1071-8 pubmed
	Orlandi R, Menard S, Colnaghi M, Boyer C, Felici F. Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides. Eur J Immunol. 1994;24:2868-73 pubmed
	Tagliabue E, Centis F, Campiglio M, Mastroianni A, Martignone S, Pellegrini R, et al. Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification. Int J Cancer. 1991;47:933-7 pubmed
	Centis F, Tagliabue E, Uppugunduri S, Pellegrini R, Martignone S, Mastroianni A, et al. p185 HER2/neu epitope mapping with murine monoclonal antibodies. Hybridoma. 1992;11:267-76 pubmed

product information

Product ID :

ALX-804-573

Catalog Number :

ALX-804-573-C100

Product Name :

c-erbB-2 (human) monoclonal antibody (MGR2)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

20164240, 19276287, 15705909, 7525309, 1672668, 1379973

Clone :

MGR2

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.

ALTnames :

ErbB2, HER-2, neu

Immunogen :

CaLu 3 lung carcinoma cell line.

Specificity :

Recognizes an epitope present in the extracellular domain of c-erbB-2 (HER-2; neu).

Buffer :

Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.

Uses :

Immunoprecipitation: Detects a band of ~185kDa.

Application Summary :

FC, IHC (FS), IP

Storage :

+4°C

more info or order :

Enzo Life Sciences product webpage