product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
CHOP monoclonal antibody (9C8)
catalog :
ALX-804-551-C100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9C8

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
Enzo Life Sciences product webpage
citations: 11
Published Application/Species/Sample/DilutionReference
  • western blot; human
Michel S, Canonne M, Arnould T, Renard P. Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. Mitochondrion. 2015;21:58-68 pubmed publisher
Happo L, Cragg M, Phipson B, Haga J, Jansen E, Herold M, et al. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood. 2010;116:5256-67 pubmed publisher
Chakraborty P, Lee W, Molitor M, Wolff N, Thevenod F. Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells. Mol Cancer. 2010;9:102 pubmed publisher
Christis C, Fullaondo A, Schildknegt D, Mkrtchian S, Heck A, Braakman I. Regulated increase in folding capacity prevents unfolded protein stress in the ER. J Cell Sci. 2010;123:787-94 pubmed publisher
Gramolini A, Kislinger T, Alikhani Koopaei R, Fong V, Thompson N, Isserlin R, et al. Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Mol Cell Proteomics. 2008;7:519-33 pubmed
Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti J, et al. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999;96:5025-30 pubmed
Sok J, Wang X, Batchvarova N, Kuroda M, Harding H, Ron D. CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol. 1999;19:495-504 pubmed
Wang X, Harding H, Zhang Y, Jolicoeur E, Kuroda M, Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 1998;17:5708-17 pubmed
Wang X, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, et al. Identification of novel stress-induced genes downstream of chop. EMBO J. 1998;17:3619-30 pubmed
Saisanit S, Sun X. Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins. Mol Cell Biol. 1997;17:844-50 pubmed
Wang X, Lawson B, Brewer J, Zinszner H, Sanjay A, Mi L, et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol. 1996;16:4273-80 pubmed
product information
Product ID :
ALX-804-551
Catalog Number :
ALX-804-551-C100
Product Name :
CHOP monoclonal antibody (9C8)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
20829369, 20459685, 20144991, 18056057, 10220412, 9858573, 9755171, 9649432, 9001238, 8754828
Clone :
9C8
Isotype :
IgG2b
SPECIES REACTIVITY :
Human, Mouse
Background :
CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP α and β. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.
ALTnames :
C/EBP homology protein, Growth arrest and DNA damage inducible protein 153, GADD153
Immunogen :
Recombinant mouse CHOP (C/EBP homology protein).
Specificity :
Recognizes an N-terminal epitope.
Buffer :
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
Uses :
Detects a band of ~31kDa by Western blot.
Application Summary :
ICC, IP, WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.