Caspase-1 (mouse) monoclonal antibody (1H11) | Enzo Life Sciences ALX-804-530-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Caspase-1 (mouse) monoclonal antibody (1H11)

catalog :

ALX-804-530-C100

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1H11

The same clone is also sold as:

Abnova: MAB3427

reactivity :

mouse

application :

western blot, ELISA, flow cytometry

citations: 2

Reference
van Delft M, Smith D, Lahoud M, Huang D, Adams J. Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases. Cell Death Differ. 2010;17:821-32 pubmed publisher
Marsden V, Kaufmann T, O Reilly L, Adams J, Strasser A. Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death. Blood. 2006;107:1872-7 pubmed

product information

Product ID :

ALX-804-530

Catalog Number :

ALX-804-530-C100

Product Name :

Caspase-1 (mouse) monoclonal antibody (1H11)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

19911005, 16291596, 16291596

Clone :

1H11

Isotype :

IgG1

SPECIES REACTIVITY :

Mouse

Background :

Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa. Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.

ALTnames :

IL-1β converting enzyme, Interleukin-1β converting enzyme, ICE

Immunogen :

p20 fragment of mouse caspase-1 and synthetic peptide corresponding to aa 206-220 (T206ALEMVKEVKEFAAC220) of mouse caspase-1.

Specificity :

Recognizes an epitope within the p20 fragment of caspase-1.

Buffer :

Liquid. Protein G Sepharose™ purified antibody in PBS containing 0.02% sodium azide.

Uses :

Detects a band of ~45kDa by Western blot.

Application Summary :

ELISA, FC, WB

Storage :

-20°C