This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Caspase-11 (mouse) monoclonal antibody (8A5)
catalog :
ALX-804-494-C100
quantity :
100 µg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
8A5
reactivity :
mouse, rat
application :
western blot, flow cytometry
product information
Product ID :
ALX-804-494
Catalog Number :
ALX-804-494-C100
Product Name :
Caspase-11 (mouse) monoclonal antibody (8A5)
Host species :
Rat
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
Clone :
8A5
Isotype :
IgG1
SPECIES REACTIVITY :
Mouse, Rat
Background :
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
Immunogen :
p20 fragment of mouse caspase-11.
Specificity :
The epitope is in the p20 fragment.
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Uses :
Detects two bands of ~38kDa and ~43kDa by Western blot.
Application Summary :
FC, WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.