Proteinase inhibitor 9 (human) monoclonal antibody (PI9-17) | Enzo Life Sciences ALX-804-457-C125 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Proteinase inhibitor 9 (human) monoclonal antibody (PI9-17)

catalog :

ALX-804-457-C125

quantity :

125 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PI9-17

reactivity :

human

application :

western blot, immunohistochemistry

citations: 7

Reference
Kummer J, Micheau O, Schneider P, Bovenschen N, Broekhuizen R, Quadir R, et al. Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis. Cell Death Differ. 2007;14:1486-96 pubmed
van Houdt I, Oudejans J, van den Eertwegh A, Baars A, Vos W, Bladergroen B, et al. Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. Clin Cancer Res. 2005;11:6400-7 pubmed
Riemersma S, Oudejans J, Vonk M, Dreef E, Prins F, Jansen P, et al. High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis. J Pathol. 2005;206:328-36 pubmed
Rowshani A, Florquin S, Bemelman F, Kummer J, Hack C, ten Berge I. Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int. 2004;66:1417-22 pubmed
Kannan Thulasiraman P, Shapiro D. Modulators of inflammation use nuclear factor-kappa B and activator protein-1 sites to induce the caspase-1 and granzyme B inhibitor, proteinase inhibitor 9. J Biol Chem. 2002;277:41230-9 pubmed
Bladergroen B, Meijer C, ten Berge R, Hack C, Muris J, Dukers D, et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?. Blood. 2002;99:232-7 pubmed
Bladergroen B, Strik M, Bovenschen N, van Berkum O, Scheffer G, Meijer C, et al. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol. 2001;166:3218-25 pubmed

product information

Product ID :

ALX-804-457

Catalog Number :

ALX-804-457-C125

Product Name :

Proteinase inhibitor 9 (human) monoclonal antibody (PI9-17)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

125 µg

list of Pubmed id :

17479112, 16144945, 15887291, 15458434, 12177049, 11756176, 11207275

Clone :

PI9-17

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis.

ALTnames :

PI9, Serpin B9, CAP3, Cytoplasmic antiproteinase 3

Immunogen :

Recombinant human full-length PI9 (proteinase inhibitor 9).

Buffer :

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Uses :

Detects bands of ~42kDa (native PI9) and ~67kDa (PI9 complexed to granzyme B) by Western blot. Not suitable for Flow Cytometry.

Application Summary :

IHC (PS), WB

Storage :

-20°C