Aryl hydrocarbon receptor monoclonal antibody (RPT1) | Enzo Life Sciences ALX-804-421-R100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Aryl hydrocarbon receptor monoclonal antibody (RPT1)

catalog :

ALX-804-421-R100

quantity :

100 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RPT1

The same clone is also sold as:

Novus Biologicals: NB300-530
Invitrogen: MA1-514

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 4

Reference
Jang E, Jang H, Shi P, Popa G, Jeoung M, Galperin E. Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5. J Cell Sci. 2015;128:4428-41 pubmed publisher
Barroso Chinea P, Thiolat M, Bido S, Martinez A, Doudnikoff E, Baufreton J, et al. D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly. Neurobiol Dis. 2015;78:77-87 pubmed publisher
Kimura Y, Kurata Y, Ishikawa A, Okayama A, Kamita M, Hirano H. N-Terminal methylation of proteasome subunit Rpt1 in yeast. Proteomics. 2013;13:3167-74 pubmed publisher
Chen H, Perdew G. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. J Biol Chem. 1994;269:27554-8 pubmed

product information

Product ID :

ALX-804-421

Catalog Number :

ALX-804-421-R100

Product Name :

Aryl hydrocarbon receptor monoclonal antibody (RPT1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µl

list of Pubmed id :

7961671

Clone :

RPT1

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor. Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.

ALTnames :

AhR

Immunogen :

Synthetic peptide corresponding to aa 12-17 (R12KRRKP17) and aa 22-31 (V22KPIPAEGIK31) of mouse AhR (aryl hydrocarbon receptor).

Buffer :

Liquid. Ascites containing 0.05% sodium azide.

Uses :

Detects a band of ~95kDa by Western blot.

Application Summary :

IF, IHC (PS), IP, WB

Storage :

-20°C