Noxa monoclonal antibody (114C307.1) | Enzo Life Sciences ALX-804-408-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Noxa monoclonal antibody (114C307.1)

catalog :

ALX-804-408-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

114C307.1

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Enzo Life Sciences product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 4a	Hagenbuchner J, Obsilova V, Kaserer T, Kaiser N, Rass B, Psenakova K, et al. Modulating FOXO3 transcriptional activity by small, DBD-binding molecules. elife. 2019;8: pubmed publisher
western blot; human; fig 1	Gilormini M, Malesys C, Armandy E, Manas P, Guy J, Magne N, et al. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. 2016;7:16731-44 pubmed publisher
western blot; human; fig 2	Le Pen J, Maillet L, Sarosiek K, Vuillier C, Gautier F, Montessuit S, et al. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Cell Death Dis. 2016;7:e2083 pubmed publisher
western blot; human; 1:1000; fig 8	VÃ©tillard A, JonchÃ¨re B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
western blot; human	Roufayel R, Johnston D, Mosser D. The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70. Cell Death Dis. 2014;5:e1546 pubmed publisher
western blot; human; 1:1000	Sosa Seda I, Mott J, Akazawa Y, Barreyro F, Bronk S, Kaufmann S, et al. Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition. Hepatol Res. 2010;40:701-10 pubmed publisher
	Knorr K, Schneider P, Meng X, Dai H, Smith B, Hess A, et al. MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors. Cell Death Differ. 2015;22:2133-42 pubmed publisher
	Morey T, Roufayel R, Johnston D, Fletcher A, Mosser D. Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression. J Biol Chem. 2015;290:11443-54 pubmed publisher
	Choudhary G, Al Harbi S, Mazumder S, Hill B, Smith M, Bodo J, et al. MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies. Cell Death Dis. 2015;6:e1593 pubmed publisher
	Zall H, Weber A, Besch R, Zantl N, Hacker G. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. Mol Cancer. 2010;9:164 pubmed publisher
	Ying S, Seiffert B, Hacker G, Fischer S. Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis. Infect Immun. 2005;73:1399-403 pubmed
	Erster S, Mihara M, Kim R, Petrenko O, Moll U. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol. 2004;24:6728-41 pubmed
	Yakovlev A, Di Giovanni S, Wang G, Liu W, Stoica B, Faden A. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74 pubmed
	Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-90 pubmed
	Deverman B, Cook B, Manson S, Niederhoff R, Langer E, Rosová I, et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 2002;111:51-62 pubmed

product information

Product ID :

ALX-804-408

Catalog Number :

ALX-804-408-C100

Product Name :

Noxa monoclonal antibody (114C307.1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

26045051, 25590803, 15731037, 15254240, 15102863, 12667443, 12372300

Clone :

114C307.1

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse

Immunogen :

Recombinant human Noxa.

Buffer :

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

Uses :

Detects a band of ~11kDa by Western blot.

Application Summary :

ICC, IHC (PS), WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage