product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Dnmt3a (mouse) monoclonal antibody (64B1446)
catalog :
ALX-804-370-C100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
64B1446
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation
more info or order :
Enzo Life Sciences product webpage
citations: 10
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:250; loading ...; fig 2c
Oliveira A, Hemstedt T, Freitag H, Bading H. Dnmt3a2: a hub for enhancing cognitive functions. Mol Psychiatry. 2016;21:1130-6 pubmed publisher
Wong M, Gertz B, Chestnut B, Martin L. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Front Cell Neurosci. 2013;7:279 pubmed publisher
Oka M, Meacham A, Hamazaki T, Rodic N, Chang L, Terada N. De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine. Oncogene. 2005;24:3091-9 pubmed
Stempak J, Sohn K, Chiang E, Shane B, Kim Y. Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model. Carcinogenesis. 2005;26:981-90 pubmed
Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005;79:734-46 pubmed
Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005;24:336-46 pubmed
Leu Y, Yan P, Fan M, Jin V, Liu J, Curran E, et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 2004;64:8184-92 pubmed
Yan Q, Cho E, Lockett S, Muegge K. Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol. 2003;23:8416-28 pubmed
Chen T, Ueda Y, Xie S, Li E. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002;277:38746-54 pubmed
Dennis K, Fan T, Geiman T, Yan Q, Muegge K. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001;15:2940-4 pubmed
product information
Product ID :
ALX-804-370
Catalog Number :
ALX-804-370-C100
Product Name :
Dnmt3a (mouse) monoclonal antibody (64B1446)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
15735669, 15695236, 15672446, 15616584, 15548683, 14612388, 12138111, 11711429
Clone :
64B1446
Isotype :
IgG1
SPECIES REACTIVITY :
Mouse
ALTnames :
DNA methyltransferase-3a
Immunogen :
Recombinant mouse Dnmt3a (DNA methyltransferase-3a).
Specificity :
Recognizes C-terminal epitope aa 705-908 of mouse Dnmt3a.
Buffer :
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Application Summary :
ICC, IHC, IP, WB, ChIP
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.