Caspase-2 monoclonal antibody (11B4) | Enzo Life Sciences ALX-804-356-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Caspase-2 monoclonal antibody (11B4)

catalog :

ALX-804-356-C100

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

11B4

reactivity :

human, mouse, rat, dogs

application :

western blot, immunoprecipitation, western blot knockout validation

more info or order :

Enzo Life Sciences product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; fig 1	Lopez Cruzan M, Sharma R, Tiwari M, Karbach S, Holstein D, Martin C, et al. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov. 2016;2: pubmed
western blot; human; loading ...; fig 3	Jelinek M, Kabelova A, Srámek J, Seitz J, Ojima I, Kovar J. Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells. Anticancer Res. 2017;37:1581-1590 pubmed
western blot; human; loading ...; fig 2d	Yang C, Matsuura K, Huang N, Robeson A, Huang B, Zhang L, et al. Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Oncogene. 2015;34:3264-72 pubmed publisher
western blot; mouse	Sandow J, Dorstyn L, O Reilly L, Tailler M, Kumar S, Strasser A, et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ. 2014;21:475-80 pubmed publisher
western blot; human; fig 4	Tinnikov A, Samuels H. A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli. PLoS ONE. 2013;8:e61085 pubmed publisher
western blot; human	Inoue S, Browne G, Melino G, Cohen G. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ. 2009;16:1053-61 pubmed publisher
	Pham D, Do H, Bruelle C, Kukkonen J, Eriksson O, MogollÃ³n I, et al. p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3. J Biol Chem. 2016;291:10747-58 pubmed publisher
	Garcia BelinchÃ³n M, SÃ¡nchez Osuna M, MartÃnez EscardÃ³ L, Granados Colomina C, Pascual Guiral S, Iglesias Guimarais V, et al. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death. J Biol Chem. 2015;290:20841-55 pubmed publisher
	Venkatesh A, Ma S, Le Y, Hall M, RÃ¼egg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed publisher
	Manzl C, Fava L, Krumschnabel G, Peintner L, Tanzer M, Soratroi C, et al. Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell Death Dis. 2013;4:e942 pubmed publisher
	Delgado M, Olsson M, Lincoln F, Zhivotovsky B, Rehm M. Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution. Biochim Biophys Acta. 2013;1833:2279-92 pubmed publisher
	Happo L, Cragg M, Phipson B, Haga J, Jansen E, Herold M, et al. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood. 2010;116:5256-67 pubmed publisher
	Villapol S, Bonnin P, Fau S, Baud O, Renolleau S, Charriaut Marlangue C. Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Am J Pathol. 2009;175:2111-20 pubmed publisher
	Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, et al. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009;185:291-303 pubmed publisher
	Camacho I, Singh N, Hegde V, Nagarkatti M, Nagarkatti P. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol. 2005;175:90-103 pubmed
	Yakovlev A, Di Giovanni S, Wang G, Liu W, Stoica B, Faden A. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74 pubmed
	Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004;304:843-6 pubmed
	Read S, Baliga B, Ekert P, Vaux D, Kumar S. A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol. 2002;159:739-45 pubmed

product information

Product ID :

ALX-804-356

Catalog Number :

ALX-804-356-C100

Product Name :

Caspase-2 monoclonal antibody (11B4)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

24309929, 23747563, 23596516, 20829369, 19815715, 19325570, 15972635, 15102863, 15073321, 12460989

Clone :

11B4

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Mouse, Rat, Monkey, Dog

Immunogen :

Recombinant human caspase-2 p19 fragment.

Specificity :

Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.

Buffer :

Liquid. In PBS containing 0.02% sodium azide.

Uses :

Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot. For FC, ICC and IHC (FS) use MAb to Caspase-2 (10C6) (Prod. No. ALX-804-355).

Application Summary :

IP, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage