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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Caspase-3 monoclonal antibody (31A1067)
catalog :
ALX-804-305-C100
quantity :
100 µg
price :
307 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
31A1067
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2g
Pulito C, Mori F, Sacconi A, Casadei L, Ferraiuolo M, Valerio M, et al. Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion. Oncotarget. 2015;6:18134-50 pubmed
  • western blot; human
Ferro M, Giuberti G, Zappavigna S, Perdonà S, Facchini G, Sperlongano P, et al. Chondroitin sulphate enhances the antitumor activity of gemcitabine and mitomycin-C in bladder cancer cells with different mechanisms. Oncol Rep. 2012;27:409-15 pubmed publisher
  • western blot; human; 1:2000
Kasman L, Lu P, Voelkel Johnson C. The histone deacetylase inhibitors depsipeptide and MS-275, enhance TRAIL gene therapy of LNCaP prostate cancer cells without adverse effects in normal prostate epithelial cells. Cancer Gene Ther. 2007;14:327-34 pubmed
Salva K, Kim Y, Rahbar Z, Wood G. Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma. Photochem Photobiol. 2018;94:1058-1065 pubmed publisher
Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, et al. Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Clin Cancer Res. 2016;22:1138-49 pubmed publisher
Weiss R, Laengle J, Sachet M, Shurygina A, Kiselev O, Egorov A, et al. Interleukin-24 inhibits influenza A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis. Antiviral Res. 2015;123:93-104 pubmed publisher
Sun J, Luo H, Nie W, Xu X, Miao X, Huang F, et al. Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL. Int J Clin Exp Pathol. 2015;8:6519-25 pubmed
Aredia F, Giansanti V, Mazzini G, Savio M, Ortiz L, Jaadane I, et al. Multiple effects of the Na(+)/H (+) antiporter inhibitor HMA on cancer cells. Apoptosis. 2013;18:1586-98 pubmed publisher
Kota V, Dhople V, Fullbright G, Smythe N, Szulc Z, Bielawska A, et al. 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells. J Proteome Res. 2013;12:4366-75 pubmed publisher
Horova V, Hradilova N, Jelínková I, Koc M, Svadlenka J, Brazina J, et al. Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes. FEBS J. 2013;280:3436-50 pubmed publisher
Böing A, Stap J, Hau C, Afink G, Ris Stalpers C, Reits E, et al. Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles. Biochim Biophys Acta. 2013;1833:1844-52 pubmed publisher
Hossain A, Radwan F, Doonan B, God J, Zhang L, Bell P, et al. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012;17:1066-78 pubmed publisher
Coupienne I, Fettweis G, Piette J. RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. Lasers Surg Med. 2011;43:557-64 pubmed publisher
Xu D, Meyer F, Ehlers E, Blasnitz L, Zhang L. Interferon regulatory factor 4 (IRF-4) targets IRF-5 to regulate Epstein-Barr virus transformation. J Biol Chem. 2011;286:18261-7 pubmed publisher
Coupienne I, Bontems S, Dewaele M, Rubio N, Habraken Y, Fulda S, et al. NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy. Biochem Pharmacol. 2011;81:606-16 pubmed publisher
Goval J, Thielen C, Bourguignon C, Greimers R, Dejardin E, Choi Y, et al. The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. Haematologica. 2008;93:1169-77 pubmed publisher
product information
Product ID :
ALX-804-305
Catalog Number :
ALX-804-305-C100
Product Name :
Caspase-3 monoclonal antibody (31A1067)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
List Price (USD) :
307 USD
list of Pubmed id :
26367324, 26261530, 23996609, 23987666, 23678861, 23531593, 22847295, 22057483, 22052369, 21454650
Image Legend 4 :
Figure 2: Western blot analysis of Caspase-3 in multiple human tissues using MAb to Caspase-3 (31A1067) (Prod. No. ALX-804-305) at 2µg/ml.  Tissues shown are A) brain, B) heart, C) intestine, D) kidney, E) liver, F) lung, G) muscle, H) stomach, I) spleen, J) ovary, and K) testis.
Image Legend 5 :
Figure 1: Western blot analysis for detection of Caspase-3 activation in HeLa cells. Cells were treated with 2mM staurosporine for different time periods. Caspase-3 activation is determined by cleavage of procaspase-3, which generates 17 and 12kDa, larger and smaller catalytic subunit, respectively.
Clone :
31A1067
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Mouse, Rat
Immunogen :
Recombinant human caspase-3.
Specificity :
Recognizes procaspase-3 and cleaved 17kDa catalytic subunit of caspase-3. Recognizes an epitope in the large (17kDa) domain subunit of caspase-3.
Buffer :
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Application Summary :
IHC (FS), IHC (PS), WB
Storage :
-20°C
more info or order :
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.