TRAIL-R1 (human) monoclonal antibody (HS101) (ATTO 647N conjugate) | Enzo Life Sciences ALX-804-297TS-T100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

TRAIL-R1 (human) monoclonal antibody (HS101) (ATTO 647N conjugate)

catalog :

ALX-804-297TS-T100

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

ATTO 647N

clone name :

HS101

reactivity :

human

application :

immunocytochemistry, flow cytometry

citations: 10

Reference
Contassot E, Kerl K, Roques S, Shane R, Gaide O, Dupuis M, et al. Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression. Blood. 2008;111:4780-7 pubmed publisher
Izeradjene K, Douglas L, Delaney A, Houghton J. Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res. 2004;64:8036-44 pubmed
Wachter T, Sprick M, Hausmann D, Kerstan A, McPherson K, Stassi G, et al. cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes. J Biol Chem. 2004;279:52824-34 pubmed
Ganten T, Haas T, Sykora J, Stahl H, Sprick M, Fas S, et al. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ. 2004;11 Suppl 1:S86-96 pubmed
Tecchio C, Huber V, Scapini P, Calzetti F, Margotto D, Todeschini G, et al. IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells. Blood. 2004;103:3837-44 pubmed
Secchiero P, Melloni E, Heikinheimo M, Mannisto S, Di Pietro R, Iacone A, et al. TRAIL regulates normal erythroid maturation through an ERK-dependent pathway. Blood. 2004;103:517-22 pubmed
Washburn B, Weigand M, Grosse Wilde A, Janke M, Stahl H, Rieser E, et al. TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. J Immunol. 2003;170:1814-21 pubmed
Leverkus M, Sprick M, Wachter T, Mengling T, Baumann B, Serfling E, et al. Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation. Mol Cell Biol. 2003;23:777-90 pubmed
Söderström T, Poukkula M, Holmström T, Heiskanen K, Eriksson J. Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J Immunol. 2002;169:2851-60 pubmed
Sprick M, Rieser E, Stahl H, Grosse Wilde A, Weigand M, Walczak H. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J. 2002;21:4520-30 pubmed

product information

Product ID :

ALX-804-297TS

Catalog Number :

ALX-804-297TS-T100

Product Name :

TRAIL-R1 (human) monoclonal antibody (HS101) (ATTO 647N conjugate)

Host species :

Mouse

Clonality :

Monoclonal

Conjugation :

ATTO 647N

Product Type :

Antibody

Size :

100 tests

list of Pubmed id :

18314443, 15520213, 15459191, 15105837, 14726404, 12969966, 12574346, 12529384, 12218097, 12198154

Clone :

HS101

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated. receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-κB.

ALTnames :

TRAIL receptor 1, Apo-2, CD261, DR4, Death receptor 4, TNFRSF 10A, TNF-related apoptosis-inducing ligand receptor 1, Tumor necrosis factor receptor superfamily member 10A

Immunogen :

Recombinant human TRAIL-R1.

Buffer :

Liquid. 100µg in PBS containing 0.02% sodium azide.

Application Summary :

FC, ICC

Storage :

+4°C