β-Catenin monoclonal antibody (8E4) | Enzo Life Sciences ALX-804-260-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

β-Catenin monoclonal antibody (8E4)

catalog :

ALX-804-260-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8E4

The same clone is also sold as:

OriGene: AM00017PU-N

reactivity :

human, mouse, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

citations: 6

Reference
Su Y, Chang Y, Lin W, Liang C, Lee J. An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/Î²-catenin-elicited promotion of the cancer stem cell phenotype. Oncogenesis. 2015;4:e157 pubmed publisher
van Noort M, Weerkamp F, Clevers H, Staal F. Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools. Blood. 2007;110:2778-9 pubmed
Derksen P, Tjin E, Meijer H, Klok M, MacGillavry H, van Oers M, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A. 2004;101:6122-7 pubmed
Boon E, Keller J, Wormhoudt T, Giardiello F, Offerhaus G, van der Neut R, et al. Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. Br J Cancer. 2004;90:224-9 pubmed
Diks S, Hardwick J, Diab R, van Santen M, Versteeg H, van Deventer S, et al. Activation of the canonical beta-catenin pathway by histamine. J Biol Chem. 2003;278:52491-6 pubmed
Schmelz E, Roberts P, Kustin E, Lemonnier L, Sullards M, Dillehay D, et al. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res. 2001;61:6723-9 pubmed

product information

Product ID :

ALX-804-260

Catalog Number :

ALX-804-260-C100

Product Name :

β-Catenin monoclonal antibody (8E4)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

26075748, 17881649, 15067127, 14710233, 14563838, 11559543

Clone :

8E4

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Dog

Immunogen :

Synthetic peptide corresponding to human β-catenin aa 27-37 conjugated to KLH.

Specificity :

Recognizes an epitope between aa 27-37 and an additional epitope in the C-Terminal region.

Buffer :

Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.

Uses :

For specific detection of dephospho-β-catenin use Prod. No. ALX-804-259.

Application Summary :

ELISA, ICC, IHC (PS), WB

Storage :

-20°C