product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
RANKL monoclonal antibody (12A380)
catalog :
ALX-804-244-C100
quantity :
100 µg
price :
349 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
12A380
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, flow cytometry
more info or order :
Enzo Life Sciences product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; rat; 1:800; fig 5a,5c
Liu Z, Liu L, Kang C, Xie Q, Zhang B, Li Y. Effects of estrogen deficiency on microstructural changes in rat alveolar bone proper and periodontal ligament. Mol Med Rep. 2015;12:3508-14 pubmed publisher
Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater A, et al. Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. Blood. 2001;98:2784-90 pubmed
Shetty R, Pepin A, Charest A, Perron J, Doyle D, Voisine P, et al. Expression of bone-regulatory proteins in human valve allografts. Heart. 2006;92:1303-8 pubmed
Yoneda T, Ishimaru N, Arakaki R, Kobayashi M, Izawa T, Moriyama K, et al. Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. Endocrinology. 2004;145:2384-91 pubmed
product information
Product ID :
ALX-804-244
Catalog Number :
ALX-804-244-C100
Product Name :
RANKL monoclonal antibody (12A380)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
List Price (USD) :
349 USD
list of Pubmed id :
16449517, 14726437, 11675352
Clone :
12A380
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Mouse
Background :
RANKL (TRANCE, OPGL, ODF) is a member of the TNF family. RANKL (receptor activator of NF-κB ligand) or TRANCE (TNF-related activation-induced cytokine receptor) has been implicated in interactions between T cells and dendritic cells. RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. RANKL is also important in T- and B-cell maturation. As OPGL (osteoprotegerin ligand) or ODF (osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. RANKL deficient mice show severe osteoporesis and complete abscence of osteoclasts as a result of lack of osteogenesis.
ALTnames :
ODF, TRANCE, OPGL, TNFSF 11, CD254
Immunogen :
Recombinant mouse RANKL (aa 1-317).
Buffer :
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Uses :
Detects a band of ~40kDa by Western blot.
Application Summary :
FC, IHC (FS), WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.