Dnmt3b monoclonal antibody (52A1018) | Enzo Life Sciences ALX-804-233-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Dnmt3b monoclonal antibody (52A1018)

catalog :

ALX-804-233-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

52A1018

The same clone is also sold as:

Active Motif: 39207
Santa Cruz Biotechnology: sc-52922

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 7

Reference
MacDonald J, Gin C, Roskams A. Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development. Dev Biol. 2005;288:461-73 pubmed
Lin T, Lee H, Chen R, Ho M, Lin C, Chen Y, et al. An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection. Cancer Lett. 2005;226:77-84 pubmed
Carlone D, Lee J, Young S, Dobrota E, Butler J, Ruiz J, et al. Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Mol Cell Biol. 2005;25:4881-91 pubmed
Leu Y, Yan P, Fan M, Jin V, Liu J, Curran E, et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 2004;64:8184-92 pubmed
Weisenberger D, Velicescu M, Cheng J, Gonzales F, Liang G, Jones P. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res. 2004;2:62-72 pubmed
Leu Y, Rahmatpanah F, Shi H, Wei S, Liu J, Yan P, et al. Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Cancer Res. 2003;63:6110-5 pubmed
Santoro R, Li J, Grummt I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002;32:393-6 pubmed

product information

Product ID :

ALX-804-233

Catalog Number :

ALX-804-233-C100

Product Name :

Dnmt3b monoclonal antibody (52A1018)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

16288735, 16004934, 15923607, 15548683, 15311210, 14757847, 14559786, 12368916

Clone :

52A1018

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse

Background :

DNA methylation is an important regulator of genetic information, shutting down gene expression through the addition of methyl groups to cytosine (C) bases in the DNA. The establishment of DNA methylation patterns requires de novo methylation that occurs predominantly during early development and gametogenesis. DNA methyltransferase-1 (Dnmt1) "maintains" C methylation after DNA replication by methylating the daughter DNA strand using the methylation pattern of the parental strand as a template. Dnmt3a and Dnmt3b are essential for the de novo methylation. They show nonoverlapping functions in development, with Dnmt3b specifically required for methylation of centromeric minor satellite repeats. Both Dnmt3a and Dnmt3b expression is elevated in several tumor cell lines comparable to Dnmt1. It has also been suggested that mutations of Dnmt3b are responsible for the ICF immunodeficiency syndrome.

ALTnames :

DNA methyltransferase-3b

Immunogen :

Recombinant mouse Dnmt3b (DNA methyltransferase-3b).

Buffer :

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

Uses :

Detects a band of ~100kDa by Western blot.

Application Summary :

ICC, IP, WB

Storage :

-20°C