Bax (human) monoclonal antibody (2D2) | Enzo Life Sciences ALX-804-225-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Bax (human) monoclonal antibody (2D2)

catalog :

ALX-804-225-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D2

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

citations: 5

Reference
Yethon J, Epand R, Leber B, Epand R, Andrews D. Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J Biol Chem. 2003;278:48935-41 pubmed
Terradillos O, Montessuit S, Huang D, Martinou J. Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett. 2002;522:29-34 pubmed
Wolter K, Hsu Y, Smith C, Nechushtan A, Xi X, Youle R. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol. 1997;139:1281-92 pubmed
Hsu Y, Youle R. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem. 1997;272:13829-34 pubmed
Hsu Y, Wolter K, Youle R. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A. 1997;94:3668-72 pubmed

product information

Product ID :

ALX-804-225

Catalog Number :

ALX-804-225-C100

Product Name :

Bax (human) monoclonal antibody (2D2)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

14522999, 12095614, 9382873, 9153240, 9108035

Clone :

2D2

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis.

ALTnames :

BCL2L4, BCL2-associated X protein

Immunogen :

Synthetic peptide corresponding to aa 3-16 of human Bax.

Specificity :

Recognizes Bax independent of its conformational state.

Buffer :

Liquid. In PBS.

Application Summary :

ELISA, ICC, IP, WB

Storage :

+4°C