Bax (active monomer) monoclonal antibody (6A7) | Enzo Life Sciences ALX-804-224-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Bax (active monomer) monoclonal antibody (6A7)

catalog :

ALX-804-224-C100

quantity :

100 µg

price :

285 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6A7

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

more info or order :

Enzo Life Sciences product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; rat western blot; mouse western blot; human	Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher
	Nie H, Xue X, Li J, Liu X, Lv S, Guan G, et al. Nitro-oleic acid attenuates OGD/R-triggered apoptosis in renal tubular cells via inhibition of Bax mitochondrial translocation in a PPAR-γ-dependent manner. Cell Physiol Biochem. 2015;35:1201-18 pubmed publisher
	Hsu Y, Wolter K, Youle R. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A. 1997;94:3668-72 pubmed
	Hsu Y, Youle R. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem. 1998;273:10777-83 pubmed
	Hsu Y, Youle R. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem. 1997;272:13829-34 pubmed
	Yethon J, Epand R, Leber B, Epand R, Andrews D. Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J Biol Chem. 2003;278:48935-41 pubmed
	Upreti M, Lyle C, Skaug B, Du L, Chambers T. Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. J Biol Chem. 2006;281:15941-50 pubmed
	Terradillos O, Montessuit S, Huang D, Martinou J. Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett. 2002;522:29-34 pubmed

product information

Product ID :

ALX-804-224

Catalog Number :

ALX-804-224-C100

Product Name :

Bax (active monomer) monoclonal antibody (6A7)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

List Price (USD) :

285 USD

list of Pubmed id :

25766531, 16574665, 14522999, 12095614, 9553144, 9153240, 9108035

Clone :

6A7

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis.

ALTnames :

BCL2L4, BCL2-associated X protein

Immunogen :

Synthetic peptide corresponding to aa 12-24 of human Bax.

Specificity :

Recognizes the active monomeric form of Bax.

Buffer :

Liquid. In PBS.

Application Summary :

ELISA, ICC, IP, WB

Storage :

+4°C

more info or order :

Enzo Life Sciences product webpage