CFTR monoclonal antibody (CF3) | Enzo Life Sciences ALX-804-214-R100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CFTR monoclonal antibody (CF3)

catalog :

ALX-804-214-R100

quantity :

100 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CF3

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Reference
Xu W, Shi Q, Chen W, Zhou C, Ni Y, Rowlands D, et al. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proc Natl Acad Sci U S A. 2007;104:9816-21 pubmed
Walker J, Watson J, Holmes C, Edelman A, Banting G. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci. 1995;108 ( Pt 6):2433-44 pubmed

product information

Product ID :

ALX-804-214

Catalog Number :

ALX-804-214-R100

Product Name :

CFTR monoclonal antibody (CF3)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µl

list of Pubmed id :

17519339, 7545688

Clone :

CF3

Isotype :

IgM

SPECIES REACTIVITY :

Human, Mouse

Background :

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (δ F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

ALTnames :

Cystic fibrosis transmembrane conductance regulator, ABCC7

Immunogen :

Synthetic peptide corresponding to aa 103-117(G103RIIASYDPDNKEER117) in the first extracellular loop of human and rabbit CFTR (cystic fibrosis transmembrane conductance regulator). This sequence is highly conserved in mouse, sheep, bovine and Xenopus laevis CFTR.

Buffer :

Liquid. Diluted ascites containing 0.05% sodium azide.

Uses :

Detects a band of ~170kDa by Western blot. Functional Application: inhibits epithelial uptake of S. typhi in some mouse cell lines.

Application Summary :

ICC, IP, WB

Storage :

-20°C