BCMA (human) monoclonal antibody (Vicky-1) | Enzo Life Sciences ALX-804-151-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

BCMA (human) monoclonal antibody (Vicky-1)

catalog :

ALX-804-151-C100

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

Vicky-1

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Notas G, Alexaki V, Kampa M, Pelekanou V, Charalampopoulos I, Sabour Alaoui S, et al. APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells. J Immunol. 2012;189:4748-58 pubmed publisher
	Lyu M, Rai D, Ahn K, Sung B, Cheung L, Marks J, et al. The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo. Neoplasia. 2010;12:366-75 pubmed
	Koarada S, Tada Y, Sohma Y, Haruta Y, Suematsu R, Mitamura M, et al. Autoantibody-producing RP105(-) B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects. Rheumatology (Oxford). 2010;49:662-70 pubmed publisher
	Pelekanou V, Kampa M, Kafousi M, Darivianaki K, Sanidas E, Tsiftsis D, et al. Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. BMC Cancer. 2008;8:76 pubmed publisher
	Sakurai D, Hase H, Kanno Y, Kojima H, Okumura K, Kobata T. TACI regulates IgA production by APRIL in collaboration with HSPG. Blood. 2007;109:2961-7 pubmed

product information

Product ID :

ALX-804-151

Catalog Number :

ALX-804-151-C100

Product Name :

BCMA (human) monoclonal antibody (Vicky-1)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

20454508, 20097906, 17119122

Clone :

Vicky-1

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.

ALTnames :

B cell maturation protein, TNFRSF 17, CD269

Immunogen :

Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No. ALX-522-026).

Buffer :

Liquid. In PBS containing 0.02% sodium azide.

Uses :

Functional Application: blocks binding of BAFF to human BCMA.

Application Summary :

ELISA, FC, ICC, WB, FUNC

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage