This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
DR6 (human) monoclonal antibody (Luke-1)
catalog :
ALX-804-150-C100
quantity :
100 µg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
Luke-1

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
product information
Product ID :
ALX-804-150
Catalog Number :
ALX-804-150-C100
Product Name :
DR6 (human) monoclonal antibody (Luke-1)
Host species :
Rat
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
Clone :
Luke-1
Isotype :
IgG2a
SPECIES REACTIVITY :
Human
Background :
Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). Several death receptors including DR3, TRAIL-R1, and TRAIL-R2 were identified. A death domain containing receptor in the TNF-R family was cloned and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified yet. T cells from DR6-deficient mice showed preference toward Th2 differentiation in vitro, suggesting that DR6, working through JNK functions to attenuate the Th2 response. Other studies of DR6-targeted mutant mice demonstrated that DR6 functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses.
ALTnames :
Death receptor-6, TNFRSF 21
Immunogen :
Recombinant human DR6 (death receptor-6) (aa 42-335) (Prod. No. ALX-522-019).
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Application Summary :
FC
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.