This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
trans-Golgi network 38 monoclonal antibody (2F7.1)
catalog :
ALX-804-095-R100
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2F7.1

The same clone is also sold as:
reactivity :
human, rat
application :
western blot, immunocytochemistry, flow cytometry
citations: 5
Reference
Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, Banting G. Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic. 2003;4:694-709 pubmed
Kawamoto K, Yoshida Y, Tamaki H, Torii S, Shinotsuka C, Yamashina S, et al. GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat. Traffic. 2002;3:483-95 pubmed
Roquemore E, Banting G. Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain. Mol Biol Cell. 1998;9:2125-44 pubmed
Reaves B, Banting G, Luzio J. Lumenal and transmembrane domains play a role in sorting type I membrane proteins on endocytic pathways. Mol Biol Cell. 1998;9:1107-22 pubmed
Horn M, Banting G. Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface. Biochem J. 1994;301 ( Pt 1):69-73 pubmed
product information
Product ID :
ALX-804-095
Catalog Number :
ALX-804-095-R100
Product Name :
trans-Golgi network 38 monoclonal antibody (2F7.1)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µl
list of Pubmed id :
12956872, 12047556, 9693371, 9571243, 8037693
Clone :
2F7.1
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Rat, Monkey
Background :
The trans-Golgi network (TGN) is part of the secretory pathway of eukaryotic cells which is distinct from the Golgi stack.The TGN is important in the later stages of protein secretion where it seems to play a key role in the sorting and targeting of secreted proteins to the correct destination. Brefeldin A (Prod. No. BML-G405) causes the contents of the Golgi stack to be redistributed into the endoplasmatic reticulum while the TGN collapse upon the microtubule organizing center. This makes immunofluorescence detection of TGN38, following Brefeldin A treatment, a useful tool for the discrimination of the TGN from the Golgi stack.
ALTnames :
TGN38
Immunogen :
Synthetic peptide corresponding to aa 1-17 (L1PSASKPNNTS. SENNPP17) of N-terminal rat TGN38 (trans-Golgi network 38).
Specificity :
Recognizes the luminal domain of TGN38.
Buffer :
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
Uses :
Detects a band of ~38kDa by Western blot, representing deglycosylated TGN38. Under normal Western blot conditions detects a band of ~85-95kDa depending on cell type.
Application Summary :
FC, ICC, WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.