Phospholamban monoclonal antibody (2D12) | Enzo Life Sciences ALX-804-093-R100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Phospholamban monoclonal antibody (2D12)

catalog :

ALX-804-093-R100

quantity :

100 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D12

The same clone is also sold as:

Invitrogen: MA3-922

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 12

Reference
Huang K, Chen Z, Jiang Y, Akare S, Kolber Simonds D, Condon K, et al. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016;15:1208-16 pubmed publisher
Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed publisher
Rothermel B, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, et al. Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics. 2005;23:18-27 pubmed
van der Velden J, Merkus D, Klarenbeek B, James A, Boontje N, Dekkers D, et al. Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. Circ Res. 2004;95:e85-95 pubmed
Nakayama M, Yan X, Price R, Borg T, Ito K, Sanbe A, et al. Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction. Am J Physiol Heart Circ Physiol. 2005;288:H317-27 pubmed
Coutu P, Metzger J. Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies. Am J Physiol Heart Circ Physiol. 2005;288:H601-12 pubmed
Liu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, et al. Autologous stem cell transplantation for myocardial repair. Am J Physiol Heart Circ Physiol. 2004;287:H501-11 pubmed
Suarez J, Gloss B, Belke D, Hu Y, Scott B, Dieterle T, et al. Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2004;287:H2164-72 pubmed
Radzyukevich T, Moseley A, Shelly D, Redden G, Behbehani M, Lingrel J, et al. The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. Am J Physiol Cell Physiol. 2004;287:C1300-10 pubmed
Gao M, Tang T, Guo T, Sun S, Feramisco J, Hammond H. Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3. J Biol Chem. 2004;279:38797-802 pubmed
Takimoto E, Soergel D, Janssen P, Stull L, Kass D, Murphy A. Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. Circ Res. 2004;94:496-504 pubmed
Kim Y, Kim S, Yatani A, Huang Y, Castelli G, Vatner D, et al. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem. 2003;278:47622-8 pubmed

product information

Product ID :

ALX-804-093

Catalog Number :

ALX-804-093-R100

Product Name :

Phospholamban monoclonal antibody (2D12)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µl

list of Pubmed id :

16033866, 15528471, 15374832, 15331372, 15277194, 15256372, 15253893, 15231818, 14726477, 13129932

Clone :

2D12

Isotype :

IgG2a

Product Description :

The antibody can also be used to increase calcium uptake in ventricular SR vesicle analogous to the phosphorylation of phospholamban following adrenergic stimulation.

SPECIES REACTIVITY :

Human, Mouse, Rat, Sheep, Rabbit, Porcine, Guinea pig, Dog, Chicken

ALTnames :

PLB

Immunogen :

Synthetic peptide corresponding to aa 2-25 (D2KVQYLTRSAIRRASTIEMPQQAR25) of dog PLB (phospholamban).

Specificity :

Recognizes an epitope between aa 9-17 of dog PLB.

Buffer :

Liquid. In PBS containing 0.05% sodium azide.

Uses :

Detects bands of ~25kDa (non-reducing conditions; representing the pentameric form of PLB) and ~5kDa (reducing conditions; representing the monomeric form of PLB) by Western blot. Functional Application: increases the calcium uptake in ventricular SR vesicles.

Application Summary :

ICC, IHC (PS), IP, WB, FUNC

Storage :

-20°C