product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
SERCA2 ATPase monoclonal antibody (IID8)
catalog :
ALX-804-048-R100
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
IID8

The same clone is also sold as:
reactivity :
human, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
Enzo Life Sciences product webpage
citations: 11
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3
Aït Ghezali L, Arbabian A, Jeibmann A, Hasselblatt M, Hallaert G, Van den Broecke C, et al. Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours. Neuropathol Appl Neurobiol. 2014;40:726-35 pubmed publisher
Sepulveda M, Hidalgo Sanchez M, Mata A. Localization of endoplasmic reticulum and plasma membrane Ca2+-ATPases in subcellular fractions and sections of pig cerebellum. Eur J Neurosci. 2004;19:542-51 pubmed
Ennis I, Li R, Murphy A, Marban E, Nuss H. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility. J Clin Invest. 2002;109:393-400 pubmed
Dode L, Van Baelen K, Wuytack F, Dean W. Low temperature molecular adaptation of the skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA 1) in the wood frog (Rana sylvatica). J Biol Chem. 2001;276:3911-9 pubmed
Lacabaratz Porret C, Launay S, Corvazier E, Bredoux R, Papp B, Enouf J. Biogenesis of endoplasmic reticulum proteins involved in Ca2+ signalling during megakaryocytic differentiation: an in vitro study. Biochem J. 2000;350 Pt 3:723-34 pubmed
Misquitta C, Sing A, Grover A. Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle. Biochem J. 1999;338 ( Pt 1):167-73 pubmed
Poch E, Leach S, Snape S, Cacic T, MacLennan D, Lytton J. Functional characterization of alternatively spliced human SERCA3 transcripts. Am J Physiol. 1998;275:C1449-58 pubmed publisher
Sharp A, McPherson P, Dawson T, Aoki C, Campbell K, Snyder S. Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain. J Neurosci. 1993;13:3051-63 pubmed
Mearow K, Thilander B, Khan I, Garfield R, Grover A. In situ hybridization and immunocytochemical localization of SERCA2 encoded Ca2+ pump in rabbit heart and stomach. Mol Cell Biochem. 1993;121:155-65 pubmed
Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, et al. Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines. Biochem J. 1994;297 ( Pt 2):343-50 pubmed
Hu P, Yin C, Zhang K, Wright L, Nixon T, Wechsler A, et al. Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching. J Biol Chem. 1995;270:11619-22 pubmed
product information
Product ID :
ALX-804-048
Catalog Number :
ALX-804-048-R100
Product Name :
SERCA2 ATPase monoclonal antibody (IID8)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µl
list of Pubmed id :
14984405, 11827999, 11044449, 10970785, 9931313, 9843705, 8392539, 8391124, 8297341, 7744801
Clone :
IID8
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Rat, Rabbit, Porcine, Dog, Bovine
Background :
ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
ALTnames :
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Immunogen :
Purified dog cardiac sarcoplasmic reticulum.
Specificity :
Recognizes the SERCA2a and SERCA2b isoforms.
Buffer :
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
Uses :
Detects a band of ~110kDa by Western blot. For detection of rat SERCA2 ATPase use MAb to SERCA2 ATPase (2A7-A1) (Prod. No. ALX-804-088).
Application Summary :
ICC, IHC (FS), WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.