HSP90 Co-chaperone monoclonal antibody (JJ3) | Enzo Life Sciences ALX-804-023-R100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90 Co-chaperone monoclonal antibody (JJ3)

catalog :

ALX-804-023-R100

quantity :

100 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JJ3

reactivity :

human, chicken

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Reference
Dittmar K, Pratt W. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem. 1997;272:13047-54 pubmed
Hu J, Toft D, Seeger C. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J. 1997;16:59-68 pubmed

product information

Product ID :

ALX-804-023

Catalog Number :

ALX-804-023-R100

Product Name :

HSP90 Co-chaperone monoclonal antibody (JJ3)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µl

list of Pubmed id :

9148915, 9009268

Clone :

JJ3

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Mouse, Rabbit, Guinea pig, Chicken

Background :

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 aa that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.

ALTnames :

Progesterone receptor complex p23, Telomerase-binding protein p23

Immunogen :

Recombinant human HSP90 Co-chaperone.

Buffer :

Liquid. Ascites diluted in PBS containing 0.05% sodium azide.

Uses :

Detects a band of ~23kDa by Western blot.

Application Summary :

ICC, IP, WB

Storage :

-20°C