Ryanodine receptor monoclonal antibody (C3-33) | Enzo Life Sciences ALX-804-015-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Ryanodine receptor monoclonal antibody (C3-33)

catalog :

ALX-804-015-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C3-33

The same clone is also sold as:

Novus Biologicals: NBP2-80143
Invitrogen: MA3-916

reactivity :

human, mouse, rat, dogs, chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 6

Reference
Du G, Guo X, Khanna V, MacLennan D. Functional characterization of mutants in the predicted pore region of the rabbit cardiac muscle Ca(2+) release channel (ryanodine receptor isoform 2). J Biol Chem. 2001;276:31760-71 pubmed
Yusufi A, Cheng J, Thompson M, Dousa T, Warner G, Walker H, et al. cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells. Am J Physiol Renal Physiol. 2001;281:F91-F102 pubmed
Sedarat F, Xu L, Moore E, Tibbits G. Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy. Am J Physiol Heart Circ Physiol. 2000;279:H202-9 pubmed
Bhat M, Hayek S, Zhao J, Zang W, Takeshima H, Wier W, et al. Expression and functional characterization of the cardiac muscle ryanodine receptor Ca(2+) release channel in Chinese hamster ovary cells. Biophys J. 1999;77:808-16 pubmed
Junker J, Sommer J, Sar M, Meissner G. Extended junctional sarcoplasmic reticulum of avian cardiac muscle contains functional ryanodine receptors. J Biol Chem. 1994;269:1627-34 pubmed
Lai F, Liu Q, Xu L, el Hashem A, Kramarcy N, Sealock R, et al. Amphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle. Am J Physiol. 1992;263:C365-72 pubmed

product information

Product ID :

ALX-804-015

Catalog Number :

ALX-804-015-C100

Product Name :

Ryanodine receptor monoclonal antibody (C3-33)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

11427530, 11399650, 10899057, 10423427, 8294409, 1325114

Clone :

C3-33

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat, Rabbit, Guinea pig, Fish, Dog, Chicken, Amphibian

Background :

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

ALTnames :

RyR

Immunogen :

Dog cardiac RyR (ryanodine receptor).

Buffer :

Liquid. Ascites diluted in PBS containing 0.05% sodium azide.

Uses :

Detects a band of 565kDa by Western blot. In non-mammalian vertebrates, a doublet is seen at 565kDa representing the α and β isoforms of the receptor.

Application Summary :

FC, ICC, IHC (FS), IHC (PS), IP, WB

Storage :

-20°C