c-IAP2 monoclonal antibody (human) (16E-6-3) | Enzo Life Sciences ALX-803-341-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

c-IAP2 monoclonal antibody (human) (16E-6-3)

catalog :

ALX-803-341-C100

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

16E-6-3

reactivity :

human

application :

western blot

more info or order :

Enzo Life Sciences product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3a	van Wijk S, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, et al. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-?B and restricts bacterial proliferation. Nat Microbiol. 2017;2:17066 pubmed publisher
western blot; human; 1:500; fig 4d	Seidelin J, Larsen S, Linnemann D, Vainer B, Coskun M, Troelsen J, et al. Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation. Am J Physiol Gastrointest Liver Physiol. 2015;308:G92-9 pubmed publisher
western blot; human; fig s1	Takeda A, Oberoi Khanuja T, Glatz G, Schulenburg K, Scholz R, Carpy A, et al. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014;33:1784-801 pubmed publisher
	Darding M, Feltham R, Tenev T, Bianchi K, Benetatos C, Silke J, et al. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011;18:1376-86 pubmed publisher
	Lluis J, Nachbur U, Cook W, Gentle I, Moujalled D, Moulin M, et al. TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. PLoS ONE. 2010;5:e8620 pubmed publisher
	Geserick P, Hupe M, Moulin M, Wong W, Feoktistova M, Kellert B, et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol. 2009;187:1037-54 pubmed publisher
	Vince J, Pantaki D, Feltham R, Mace P, Cordier S, Schmukle A, et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem. 2009;284:35906-15 pubmed publisher
	Vince J, Chau D, Callus B, Wong W, Hawkins C, Schneider P, et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008;182:171-84 pubmed publisher
	Vince J, Wong W, Khan N, Feltham R, Chau D, Ahmed A, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell. 2007;131:682-93 pubmed
	Silke J, Kratina T, Chu D, Ekert P, Day C, Pakusch M, et al. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 2005;102:16182-7 pubmed

product information

Product ID :

ALX-803-341

Catalog Number :

ALX-803-341-C100

Product Name :

c-IAP2 monoclonal antibody (human) (16E-6-3)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

21331077, 20062539, 20038679, 19815541, 18606850, 18022363, 16263936

Clone :

16E-6-3

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 aa BIR (baculovirus inhibitor repeat) domain. Human members of the family include c-IAP1, c-IAP2, XIAP, survivin, livin and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7 and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks its interaction with caspase-9, thereby allowing the processing and activation of the caspase.

ALTnames :

HIAP-1, BIRC3, Baculoviral IAP repeat-containing protein-3, Cellular inhibitor of apoptosis-2, Human inhibitor of apoptosis protein-1, RNF49, API2

Immunogen :

GST-fusion product of the CARD domain of human c-IAP2.

Buffer :

Liquid. 0.2µm-filtered solution in PBS containing 50% glycerol.

Application Summary :

Storage :

-80°C

more info or order :

Enzo Life Sciences product webpage