This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
VRK1 (human) (1F6) monoclonal antibody
catalog :
ALX-803-321-C100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1F6

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation
citations: 7
Reference
López Sánchez I, Sanz Garcia M, Lazo P. Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. Mol Cell Biol. 2009;29:1189-201 pubmed publisher
MacLaine N, Oster B, Bundgaard B, Fraser J, Buckner C, Lazo P, et al. A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. J Biol Chem. 2008;283:28563-73 pubmed publisher
Sanz Garcia M, López Sánchez I, Lazo P. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. Mol Cell Proteomics. 2008;7:2199-214 pubmed publisher
Valbuena A, López Sánchez I, Lazo P. Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. PLoS ONE. 2008;3:e1642 pubmed publisher
Valbuena A, López Sánchez I, Vega F, Sevilla A, Sanz Garcia M, Blanco S, et al. Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. Arch Biochem Biophys. 2007;465:219-26 pubmed
Santos C, Rodriguez Pinilla M, Vega F, Rodriguez Peralto J, Blanco S, Sevilla A, et al. VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res. 2006;4:177-85 pubmed
Vega F, Sevilla A, Lazo P. p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol Cell Biol. 2004;24:10366-80 pubmed
product information
Product ID :
ALX-803-321
Catalog Number :
ALX-803-321-C100
Product Name :
VRK1 (human) (1F6) monoclonal antibody
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
19103756, 18669630, 18617507, 18286197, 17617371, 16547155, 15542844
Clone :
1F6
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
Vaccinia-related kinase 1 (VRK1) contributes to p53 stabilization by partly interfering with its MDM2-mediated degradation.
ALTnames :
Serine/threonine protein kinase VRK1, Vaccinia-related kinase 1
Immunogen :
Recombinant human VRK1 (vaccinia-related kinase 1).
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Application Summary :
IHC (PS), IP, WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.