This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
RUNX3 (human) monoclonal antibody (R3-6E9)
catalog :
ALX-803-318-C100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
R3-6E9
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation
citations: 4
Reference
Lee J, Pyon J, Kim D, Lee S, Nam H, Kang S, et al. Expression of RUNX3 in skin cancers. Clin Exp Dermatol. 2011;36:769-74 pubmed publisher
Chen W, Salto Tellez M, Palanisamy N, Ganesan K, Hou Q, Tan L, et al. Targets of genome copy number reduction in primary breast cancers identified by integrative genomics. Genes Chromosomes Cancer. 2007;46:288-301 pubmed
Lau Q, Raja E, Salto Tellez M, Liu Q, Ito K, Inoue M, et al. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res. 2006;66:6512-20 pubmed
Ito K, Liu Q, Salto Tellez M, Yano T, Tada K, Ida H, et al. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 2005;65:7743-50 pubmed
product information
Product ID :
ALX-803-318
Catalog Number :
ALX-803-318-C100
Product Name :
RUNX3 (human) monoclonal antibody (R3-6E9)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
17171680, 16818622, 16140942
Clone :
R3-6E9
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells.
ALTnames :
Core-binding factor α3 subunit, AML-2, Acute myeloid leukemia 2 protein, CBF-α3, Runt-related transcription factor 3
Immunogen :
Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300).
Buffer :
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Application Summary :
IHC (PS), IP, WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.