CD51 (human) monoclonal antibody (L230) | Enzo Life Sciences ALX-803-304-C100 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CD51 (human) monoclonal antibody (L230)

catalog :

ALX-803-304-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L230

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig s5a	Owen L, Adhikari A, Patel M, Grimmer P, Leijnse N, Kim M, et al. A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix. Mol Biol Cell. 2017;28:1959-1974 pubmed publisher
	Nevo J, Mai A, Tuomi S, Pellinen T, Pentikäinen O, Heikkila P, et al. Mammary-derived growth inhibitor (MDGI) interacts with integrin ?-subunits and suppresses integrin activity and invasion. Oncogene. 2010;29:6452-63 pubmed publisher
	Tuomi S, Mai A, Nevo J, Laine J, Vilkki V, Ohman T, et al. PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal. 2009;2:ra32 pubmed publisher
	Williams C, Kajander T, Hyypia T, Jackson T, Sheppard D, Stanway G. Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol. 2004;78:6967-73 pubmed
	Di Stefano P, Cabodi S, Boeri Erba E, Margaria V, Bergatto E, Giuffrida M, et al. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell. 2004;15:787-800 pubmed
	Moro L, Dolce L, Cabodi S, Bergatto E, Boeri Erba E, Smeriglio M, et al. Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem. 2002;277:9405-14 pubmed
	Schwartz B, Karsan A, Bombeli T, Harlan J. A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells. J Immunol. 1999;162:4842-8 pubmed
	Weinacker A, Chen A, Agrez M, Cone R, Nishimura S, Wayner E, et al. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994;269:6940-8 pubmed

product information

Product ID :

ALX-803-304

Catalog Number :

ALX-803-304-C100

Product Name :

CD51 (human) monoclonal antibody (L230)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

20802519, 19567915, 15194773, 14657239, 11756413, 10202028, 8120056

Clone :

L230

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.

ALTnames :

αV integrin, Vitronectin receptor α subunit

Immunogen :

Human endothelial cells.

Specificity :

Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6.

Buffer :

Liquid. In PBS containing 0.05% sodium azide.

Uses :

Functional Application: αV integrin blocking

Application Summary :

ELISA, FC, IF, IHC, IP, FUNC

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage