This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Proliferating cell nuclear antigen monoclonal antibody (PC10)
catalog :
ALX-801-091-L001
quantity :
1 ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PC10

The same clone is also sold as:
reactivity :
human, mouse, rat, dogs
application :
immunohistochemistry
product information
Product ID :
ALX-801-091
Catalog Number :
ALX-801-091-L001
Product Name :
Proliferating cell nuclear antigen monoclonal antibody (PC10)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
1 ml
Clone :
PC10
Isotype :
IgG2a
SPECIES REACTIVITY :
Vertebrate, Schizosaccharomyces pombe, Insect
Background :
Proliferating Cell Nuclear Antigen (PCNA) is associated with the DNA replication fork and its major function is described as a processivity factor for replicative DNA polymerases (polymerases δ and ε ) acting as a sliding clamp. It has a highly conserved amino acid sequence and has been identified in all eukaryotes and is being used as a proliferating marker. PCNA is also able to interact with multiple partners involved in Okazaki fragment joining, DNA repair, DNA methylation and chromatin assembly. In DNA repair PCNA has been reported not only for nucleotide excision repair (NER) (in concert with XPG and ERCC1), but also for base excision repair (BER) (binding to uracil-DNA glycosylase) and mismatch repair (MMR) (binding to mismatch repair enzymes MSH2 & MLH1). It is further associated with cell cycle control through cdk-cyclins during G1 to S phase.
ALTnames :
PCNA
Immunogen :
Recombinant rat PCNA (proliferating cell nuclear antigen).
Specificity :
Intense nuclear staining of proliferating cells in normal and tumor tissues.
Buffer :
Liquid. In 0.01M PBS containing 0.1% sodium azide and 1% BSA.
Application Summary :
IHC (PS)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.