GCDFP-15 (human) monoclonal antibody (D6) | Enzo Life Sciences ALX-801-051-L001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

GCDFP-15 (human) monoclonal antibody (D6)

catalog :

ALX-801-051-L001

quantity :

1 ml

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D6

The same clone is also sold as:

Abcam: ab86721

reactivity :

human

application :

immunohistochemistry

citations: 4

Reference
Fan C, Wang J, Barnes E. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000;24:579-86 pubmed
Mazoujian G, Pinkus G, Haagensen D. Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins. Am J Surg Pathol. 1984;8:43-50 pubmed
Mazoujian G, Pinkus G, Davis S, Haagensen D. Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am J Pathol. 1983;110:105-12 pubmed
Wick M, Lillemoe T, Copland G, Swanson P, Manivel J, Kiang D. Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol. 1989;20:281-7 pubmed

product information

Product ID :

ALX-801-051

Catalog Number :

ALX-801-051-L001

Product Name :

GCDFP-15 (human) monoclonal antibody (D6)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

1 ml

list of Pubmed id :

10757407, 6198933, 6130702, 2542151

Clone :

Isotype :

IgG2a

SPECIES REACTIVITY :

Human

Background :

Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP-15 to be a highly specific and sensitive marker for breast cancer. GCDFP-15 is expressed by apocrine sweat glands, eccrine glands (variable), minor salivary glands, bronchial glands, metaplasmic epithelium of the breast, benign sweat gland tumors of the skin and the serous cells of the submandibular gland. Breast carcinomas (primary and metastatic lesions) with apocrine features express GCDFP-15. GCDFP-15 is positive in extramammary Paget's Disease. Other tumors tested are negative.

ALTnames :

BRST-2

Immunogen :

GCDFP-15 (gross cystic disease fluid protein-15; BRST-2).

Buffer :

Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide .

Uses :

This antibody is heat sensitive. Paraffin sections that have been heat fixed at 60°C may lose antibody binding site.

Application Summary :

IHC (PS)

Storage :

-20°C