MRP2 monoclonal antibody (M2III-6) | Enzo Life Sciences ALX-801-016-C250 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

MRP2 monoclonal antibody (M2III-6)

catalog :

ALX-801-016-C250

quantity :

250 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M2III-6

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Enzo Life Sciences product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 7a	Sayyed K, Vee M, Abdel Razzak Z, Jouan E, Stieger B, Denizot C, et al. Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate. Toxicology. 2016;363-364:58-71 pubmed publisher
western blot; human	Bernd A, Ott M, Ishikawa H, Schroten H, Schwerk C, Fricker G. Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier. Pharm Res. 2015;32:2973-82 pubmed publisher
western blot; rat; loading ...	Barosso I, Zucchetti A, Miszczuk G, Boaglio A, Taborda D, Roma M, et al. EGFR participates downstream of ERÎ± in estradiol-17Î²-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets. Arch Toxicol. 2016;90:891-903 pubmed publisher
western blot; human; fig 1	Rigalli J, Ciriaci N, Arias A, Ceballos M, Villanueva S, Luquita M, et al. Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity. PLoS ONE. 2015;10:e0119502 pubmed publisher
western blot; human	Rigalli J, Perdomo V, Luquita M, Villanueva S, Arias A, Theile D, et al. Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor. PLoS Negl Trop Dis. 2012;6:e1951 pubmed publisher
immunocytochemistry; rat western blot; rat	Rosales R, Monte M, Blazquez A, Briz O, Marin J. ABCC2 is involved in the hepatocyte perinuclear barrier for small organic compounds. Biochem Pharmacol. 2012;84:1651-9 pubmed publisher
immunocytochemistry; rat western blot; rat	Tchaparian E, Houghton J, Uyeda C, Grillo M, Jin L. Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes. Drug Metab Dispos. 2011;39:2387-94 pubmed publisher
western blot; human; 1:500	Haenisch S, Laechelt S, Bruckmueller H, Werk A, Noack A, Bruhn O, et al. Down-regulation of ATP-binding cassette C2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379. Mol Pharmacol. 2011;80:314-20 pubmed publisher
	Mayati A, Moreau A, Le Vee M, Bruyère A, Jouan E, Denizot C, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018;8:16115 pubmed publisher
	Grammatikopoulos T, Sambrotta M, Strautnieks S, Foskett P, Knisely A, Wagner B, et al. Mutations in DCDC2 (doublecortin domain containing protein 2) in neonatal sclerosing cholangitis. J Hepatol. 2016;65:1179-1187 pubmed publisher
	Dröge C, Schaal H, Engelmann G, Wenning D, Haussinger D, Kubitz R. Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations. Sci Rep. 2016;6:24827 pubmed publisher
	Striz A, Tuma P. The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells. J Biol Chem. 2016;291:9721-32 pubmed publisher
	Li H, Park G, Bae N, Kim J, Oh M, Yang H. Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model. J Ethnopharmacol. 2015;176:336-44 pubmed publisher
	Arana M, Tocchetti G, Domizi P, Arias A, Rigalli J, Ruiz M, et al. Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance. Toxicol Appl Pharmacol. 2015;287:178-90 pubmed publisher
	Yang K, Pfeifer N, Hardwick R, Yue W, Stewart P, Brouwer K. An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown. Mol Pharm. 2014;11:766-75 pubmed publisher
	Luna Tortós C, Fedrowitz M, Loscher W. Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010;58:1019-32 pubmed publisher
	Honscha K, Schirmer A, Reischauer A, Schoon H, Einspanier A, Gabel G. Expression of ABC-transport proteins in canine mammary cancer: consequences for chemotherapy. Reprod Domest Anim. 2009;44 Suppl 2:218-23 pubmed publisher
	Lowes S, Simmons N. Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol. 2002;135:1263-75 pubmed
	Scheffer G, Kool M, Heijn M, de Haas M, Pijnenborg A, Wijnholds J, et al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 2000;60:5269-77 pubmed
	Hooijberg J, Broxterman H, Kool M, Assaraf Y, Peters G, Noordhuis P, et al. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999;59:2532-5 pubmed
	Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen L, et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest. 1998;101:1310-9 pubmed
	Paulusma C, Bosma P, Zaman G, Bakker C, Otter M, Scheffer G, et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science. 1996;271:1126-8 pubmed

product information

Product ID :

ALX-801-016

Catalog Number :

ALX-801-016-C250

Product Name :

MRP2 monoclonal antibody (M2III-6)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

250 µg

list of Pubmed id :

26593210, 26049102, 26049102, 20080116, 11877335, 11016657, 10363967, 9525973, 8599091

Clone :

M2III-6

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Rat

ALTnames :

Multidrug resistance-associated protein 2, cMOAT, ABCC2

Immunogen :

Recombinant C-terminal rat MRP2 (multidrug resistance-associated protein-2; cMOAT) (aa 1339-1541).

Specificity :

Recognizes an internal epitope of MRP2.

Buffer :

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Application Summary :

ICC, IHC (FS), IHC (PS), WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage