MRP1 (human) monoclonal antibody (QCRL-3) | Enzo Life Sciences ALX-801-011-L001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

MRP1 (human) monoclonal antibody (QCRL-3)

catalog :

ALX-801-011-L001

quantity :

1 ml

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

QCRL-3

The same clone is also sold as:

BD Biosciences: 557594, 557593

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 8

Reference
Hipfner D, Deeley R, Cole S. Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta. 1999;1461:359-76 pubmed
Filipits M, Stranzl T, Pohl G, Suchomel R, Zöchbauer S, Brunner R, et al. MRP expression in acute myeloid leukemia. An update. Adv Exp Med Biol. 1999;457:141-50 pubmed
Hipfner D, Mao Q, Qiu W, Leslie E, Gao M, Deeley R, et al. Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. J Biol Chem. 1999;274:15420-6 pubmed
Renes J, de Vries E, Nienhuis E, Jansen P, Muller M. ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br J Pharmacol. 1999;126:681-8 pubmed
Filipits M, Suchomel R, Dekan G, Haider K, Valdimarsson G, Depisch D, et al. MRP and MDR1 gene expression in primary breast carcinomas. Clin Cancer Res. 1996;2:1231-7 pubmed
Loe D, Almquist K, Deeley R, Cole S. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem. 1996;271:9675-82 pubmed
Hipfner D, Gauldie S, Deeley R, Cole S. Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res. 1994;54:5788-92 pubmed
Almquist K, Loe D, Hipfner D, Mackie J, Cole S, Deeley R. Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell. Cancer Res. 1995;55:102-10 pubmed

product information

Product ID :

ALX-801-011

Catalog Number :

ALX-801-011-L001

Product Name :

MRP1 (human) monoclonal antibody (QCRL-3)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

1 ml

list of Pubmed id :

10581367, 10500789, 10336431, 10188979, 9816292, 8621643, 7954400, 7805019

Clone :

QCRL-3

Isotype :

IgG2a

SPECIES REACTIVITY :

Human

ALTnames :

Multidrug resistance-associated protein 1, ABCC1

Immunogen :

Membranes prepared from the human small cell lung cancer cell line H69AR.

Specificity :

Recognizes a conformation-dependent internal epitope (aa 617-932) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines.

Buffer :

Liquid. 0.22µm-filtered antibody in PBS containing 0.7% BSA and 0.1% sodium azide.

Uses :

Flow Cytometry: cell permeabilization required. Immunocytochemistry: cytospin preparations. Functional Application: inhibits LTC4 transport. Not recommended for Western blot.

Application Summary :

FC, ICC, IHC (PS), IP, FUNC

Storage :

-20°C