P-glycoprotein (human) monoclonal antibody (MRK16) | Enzo Life Sciences ALX-801-008-C150 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

P-glycoprotein (human) monoclonal antibody (MRK16)

catalog :

ALX-801-008-C150

quantity :

150 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MRK16

The same clone is also sold as:

Kamiya Biomedical Company: MC-012
Absolute Antibody: Ab00143-1.1, Ab00143-23.0

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 1	Kumar J, Wei B, Madigan J, Simpson R, Hall M, Gottesman M. Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Sci Rep. 2016;6:20418 pubmed publisher
	Sen R, Natarajan K, Bhullar J, Shukla S, Fang H, Cai L, et al. The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Mol Cancer Ther. 2012;11:2033-44 pubmed publisher
	Goda K, Nagy H, Bene L, Balazs M, Arceci R, Mechetner E, et al. Conformational heterogeneity of P-glycoprotein. Cancer Detect Prev. 2000;24:415-21 pubmed
	Ushigome F, Takanaga H, Matsuo H, Yanai S, Tsukimori K, Nakano H, et al. Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein. Eur J Pharmacol. 2000;408:1-10 pubmed
	Dassow H, Lassner D, Remke H, Preiss R. Modulation of multidrug resistance in human leukemia cells with mdr1-targeted antisense oligonucleotides using variable treatment schedules. Int J Clin Pharmacol Ther. 2000;38:209-16 pubmed
	Gribar J, Ramachandra M, Hrycyna C, Dey S, Ambudkar S. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system. J Membr Biol. 2000;173:203-14 pubmed
	De Moerloose B, Dhooge C, Philippe J. Discordance of P-glycoprotein expression and function in acute leukemia. Adv Exp Med Biol. 1999;457:107-18 pubmed
	Rao V, Dahlheimer J, Bardgett M, Snyder A, Finch R, Sartorelli A, et al. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci U S A. 1999;96:3900-5 pubmed
	Egashira M, Kawamata N, Sugimoto K, Kaneko T, Oshimi K. P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833. Blood. 1999;93:599-606 pubmed
	Huet S, Marie J, Gualde N, Robert J. Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network. Cytometry. 1998;34:248-56 pubmed
	Smyth M, Krasovskis E, Sutton V, Johnstone R. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci U S A. 1998;95:7024-9 pubmed
	Beck W, Grogan T, Willman C, Cordon Cardo C, Parham D, Kuttesch J, et al. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res. 1996;56:3010-20 pubmed

product information

Product ID :

ALX-801-008

Catalog Number :

ALX-801-008-C150

Product Name :

P-glycoprotein (human) monoclonal antibody (MRK16)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

150 µg

list of Pubmed id :

11129983, 11070177, 10783831, 10667916, 10500786, 10097135, 9885221, 9879641, 9618532, 8674056

Clone :

MRK16

Isotype :

IgG2a

SPECIES REACTIVITY :

Human

ALTnames :

ABCB1, CD243, P-glycoprotein 1

Immunogen :

Adriamycin-resistant human myelogenous leukemia K-562/ADM cells.

Specificity :

Recognizes an external epitope of human P-glycoprotein. Also recognizes P-glycoprotein of human cortical adenomas.

Buffer :

Liquid. In PBS containing 1% BSA and 0.1% sodium azide.

Uses :

Functional Application: Inhibits P-glycoprotein function. Not recommended for Western blot (epitope recognized by this antibody may be lost in the presence of protein denaturing agents such as SDS).

Application Summary :

FC, IHC (FS), IP, FUNC

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage