MRP1 monoclonal antibody (MRPr1) | Enzo Life Sciences ALX-801-007-C250 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

MRP1 monoclonal antibody (MRPr1)

catalog :

ALX-801-007-C250

quantity :

250 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MRPr1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Kumar J, Wei B, Madigan J, Simpson R, Hall M, Gottesman M. Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Sci Rep. 2016;6:20418 pubmed publisher
western blot; mouse; loading ...; fig 1c	Zhang W, St Clair D, Butterfield A, Vore M. Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts. Toxicol Sci. 2016;151:44-56 pubmed publisher
immunocytochemistry; human; 1:250 western blot; human	Bernd A, Ott M, Ishikawa H, Schroten H, Schwerk C, Fricker G. Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier. Pharm Res. 2015;32:2973-82 pubmed publisher
immunocytochemistry; mouse western blot; mouse; 1:2000	Gibson C, Hossain M, Richardson J, Aleksunes L. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther. 2012;343:650-60 pubmed publisher
western blot; human; 1:400	Mason C, Buhimschi I, Buhimschi C, Dong Y, Weiner C, Swaan P. ATP-binding cassette transporter expression in human placenta as a function of pregnancy condition. Drug Metab Dispos. 2011;39:1000-7 pubmed publisher
	Roundhill E, Turnbull D, Burchill S. Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90Î². FASEB J. 2016;30:1712-23 pubmed publisher
	Tivnan A, Zakaria Z, O Leary C, KÃ¶gel D, Pokorny J, Sarkaria J, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015;9:218 pubmed publisher
	Cheung L, Yu D, Neiron Z, Failes T, Arndt G, Fletcher J. Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen. Biochem Pharmacol. 2015;93:380-8 pubmed publisher
	Qin L, Tam S, Deeley R. Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function. Drug Metab Dispos. 2012;40:1403-13 pubmed publisher
	Roy S, Kenny E, Kennedy S, Larkin A, Ballot J, Perez De Villarreal M, et al. MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer. Anticancer Res. 2007;27:1325-30 pubmed
	Westlake C, Payen L, Gao M, Cole S, Deeley R. Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. J Biol Chem. 2004;279:53571-83 pubmed
	Daoud R, Kast C, Gros P, Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry. 2000;39:15344-52 pubmed
	Scheffer G, Kool M, Heijn M, de Haas M, Pijnenborg A, Wijnholds J, et al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 2000;60:5269-77 pubmed
	Daoud R, Desneves J, Deady L, Tilley L, Scheper R, Gros P, et al. The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Biochemistry. 2000;39:6094-102 pubmed
	Prechtl S, Roellinghoff M, Scheper R, Cole S, Deeley R, Lohoff M. The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells. J Immunol. 2000;164:754-61 pubmed
	Meijer G, Schroeijers A, Flens M, Meuwissen S, van der Valk P, Baak J, et al. Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis. J Clin Pathol. 1999;52:450-4 pubmed
	Nuessler V, Stötzer O, Gullis E, Pelka Fleischer R, Pogrebniak A, Gieseler F, et al. Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines. Leukemia. 1999;13:1864-72 pubmed
	Arts H, Katsaros D, de Vries E, Massobrio M, Genta F, Danese S, et al. Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma. Clin Cancer Res. 1999;5:2798-805 pubmed
	Pallis M, Turzanski J, Langabeer S, Russell N. Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts. Adv Exp Med Biol. 1999;457:77-88 pubmed

product information

Product ID :

ALX-801-007

Catalog Number :

ALX-801-007-C250

Product Name :

MRP1 monoclonal antibody (MRPr1)

Host species :

Rat

Clonality :

Monoclonal

Product Type :

Antibody

Size :

250 µg

list of Pubmed id :

26136652, 15459206, 11112520, 11016657, 10821682, 10623820, 10562814, 10557064, 10537344, 10500783

Clone :

MRPr1

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Mouse

ALTnames :

Multidrug resistance-associated protein 1, ABCC1

Immunogen :

Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 192-360).

Specificity :

Recognizes the internal epitope (G238SDLWSLNKE247) of MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines.

Buffer :

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Uses :

Flow Cytometry: cell permeabilization required. Immunocytochemistry: cytospin preparations

Application Summary :

FC, ICC, IHC (FS), IHC (PS), WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage