product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
MRP1 monoclonal antibody (MRPr1)
catalog :
ALX-801-007-C125
quantity :
125 µg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MRPr1

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Enzo Life Sciences product webpage
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1
Kumar J, Wei B, Madigan J, Simpson R, Hall M, Gottesman M. Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Sci Rep. 2016;6:20418 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3d
  • western blot; human; loading ...; fig 1c
Roundhill E, Turnbull D, Burchill S. Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β. FASEB J. 2016;30:1712-23 pubmed publisher
  • immunocytochemistry; human; 1:250
  • western blot; human
Bernd A, Ott M, Ishikawa H, Schroten H, Schwerk C, Fricker G. Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier. Pharm Res. 2015;32:2973-82 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse; 1:2000
Gibson C, Hossain M, Richardson J, Aleksunes L. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther. 2012;343:650-60 pubmed publisher
  • western blot; human; 1:400
Mason C, Buhimschi I, Buhimschi C, Dong Y, Weiner C, Swaan P. ATP-binding cassette transporter expression in human placenta as a function of pregnancy condition. Drug Metab Dispos. 2011;39:1000-7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:15
Roy S, Kenny E, Kennedy S, Larkin A, Ballot J, Perez De Villarreal M, et al. MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer. Anticancer Res. 2007;27:1325-30 pubmed
Tivnan A, Zakaria Z, O Leary C, Kögel D, Pokorny J, Sarkaria J, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015;9:218 pubmed publisher
Cheung L, Yu D, Neiron Z, Failes T, Arndt G, Fletcher J. Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen. Biochem Pharmacol. 2015;93:380-8 pubmed publisher
Caceres N, Aerts M, Marquez B, Mingeot Leclercq M, Tulkens P, Devreese B, et al. Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC). PLoS ONE. 2013;8:e58285 pubmed publisher
Qin L, Tam S, Deeley R. Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function. Drug Metab Dispos. 2012;40:1403-13 pubmed publisher
Westlake C, Payen L, Gao M, Cole S, Deeley R. Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. J Biol Chem. 2004;279:53571-83 pubmed
Daoud R, Kast C, Gros P, Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry. 2000;39:15344-52 pubmed
Scheffer G, Kool M, Heijn M, de Haas M, Pijnenborg A, Wijnholds J, et al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 2000;60:5269-77 pubmed
Daoud R, Desneves J, Deady L, Tilley L, Scheper R, Gros P, et al. The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Biochemistry. 2000;39:6094-102 pubmed
Prechtl S, Roellinghoff M, Scheper R, Cole S, Deeley R, Lohoff M. The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells. J Immunol. 2000;164:754-61 pubmed
Meijer G, Schroeijers A, Flens M, Meuwissen S, van der Valk P, Baak J, et al. Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis. J Clin Pathol. 1999;52:450-4 pubmed
Nuessler V, Stötzer O, Gullis E, Pelka Fleischer R, Pogrebniak A, Gieseler F, et al. Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines. Leukemia. 1999;13:1864-72 pubmed
Arts H, Katsaros D, de Vries E, Massobrio M, Genta F, Danese S, et al. Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma. Clin Cancer Res. 1999;5:2798-805 pubmed
Pallis M, Turzanski J, Langabeer S, Russell N. Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts. Adv Exp Med Biol. 1999;457:77-88 pubmed
product information
Product ID :
ALX-801-007
Catalog Number :
ALX-801-007-C125
Product Name :
MRP1 monoclonal antibody (MRPr1)
Host species :
Rat
Clonality :
Monoclonal
Product Type :
Antibody
Size :
125 µg
list of Pubmed id :
26136652, 15459206, 11112520, 11016657, 10821682, 10623820, 10562814, 10557064, 10537344, 10500783
Clone :
MRPr1
Isotype :
IgG2a
SPECIES REACTIVITY :
Human, Mouse
ALTnames :
Multidrug resistance-associated protein 1, ABCC1
Immunogen :
Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 192-360).
Specificity :
Recognizes the internal epitope (G238SDLWSLNKE247) of MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
Buffer :
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Uses :
Flow Cytometry: cell permeabilization required. Immunocytochemistry: cytospin preparations
Application Summary :
FC, ICC, IHC (FS), IHC (PS), WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.