P-glycoprotein (human) monoclonal antibody (JSB-1) | Enzo Life Sciences ALX-801-004-C250 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

P-glycoprotein (human) monoclonal antibody (JSB-1)

catalog :

ALX-801-004-C250

quantity :

250 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JSB-1

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Enzo Life Sciences product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human	Kwan P, Li H, Al Jufairi E, Abdulla R, Gonzales M, Kaye A, et al. Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy. Neurobiol Dis. 2010;39:192-7 pubmed publisher
	Kita H, Okamoto K, Kushima R, Kawauchi A, Chano T. Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas. Oncol Lett. 2015;10:661-666 pubmed
	Willyerd F, Empey P, Philbrick A, Ikonomovic M, Puccio A, Kochanek P, et al. Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma. 2016;33:226-31 pubmed publisher
	Feldmann M, Asselin M, Liu J, Wang S, McMahon A, Anton Rodriguez J, et al. P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study. Lancet Neurol. 2013;12:777-85 pubmed publisher
	Jillella A, Murren J, Hamid K, Longley B, Edelson R, Cooper D. P-glycoprotein expression and multidrug resistance in cutaneous T-cell lymphoma. Cancer Invest. 2000;18:609-13 pubmed
	Scheffer G, Kool M, Heijn M, de Haas M, Pijnenborg A, Wijnholds J, et al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 2000;60:5269-77 pubmed
	Coley H, Verrill M, Gregson S, Odell D, Fisher C, Judson I. Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma. Eur J Cancer. 2000;36:881-8 pubmed
	Meijer G, Schroeijers A, Flens M, Meuwissen S, van der Valk P, Baak J, et al. Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis. J Clin Pathol. 1999;52:450-4 pubmed
	Kim Y, Cho S, Lee K, Hahm K, Wang H, Yim H, et al. Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma. Clin Nucl Med. 1999;24:874-9 pubmed
	Sawada T, Kato Y, Sakayori N, Takekawa Y, Kobayashi M. Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors. Brain Tumor Pathol. 1999;16:23-7 pubmed
	Poulain S, Lepelley P, Cambier N, Cosson A, Fenaux P, Wattel E. Assessment of P-glycoprotein expression by immunocytochemistry and flow cytometry using two different monoclonal antibodies coupled with functional efflux analysis in 34 patients with acute myeloid leukemia. Adv Exp Med Biol. 1999;457:57-63 pubmed
	Jimenez R, Zalupski M, Frank J, Du W, Ryan J, Lucas D. Multidrug resistance phenotype in high grade soft tissue sarcoma: correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy. Cancer. 1999;86:976-81 pubmed
	Barg S, Renstrom E, Berggren P, Bertorello A, Bokvist K, Braun M, et al. The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein. Proc Natl Acad Sci U S A. 1999;96:5539-44 pubmed

product information

Product ID :

ALX-801-004

Catalog Number :

ALX-801-004-C250

Product Name :

P-glycoprotein (human) monoclonal antibody (JSB-1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

250 µg

list of Pubmed id :

23786896, 11036468, 11016657, 10785593, 10562814, 10551471, 10532420, 10500780, 10491523, 10318919

Clone :

JSB-1

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Chinese hamster

ALTnames :

ABCB1, CD243, P-glycoprotein 1

Immunogen :

MDR (multidrug resistant) Chinese hamster ovary cells (ChrC5).

Specificity :

Recognizes a highly conserved cytoplasmic epitope of the human P-glycoprotein, the expression of which is strongly correlated with the degree of MDR derived MDR cell lines and human MDR cell lines from lung, ovaries and B cell lymphoma.

Buffer :

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Application Summary :

FC, ICC, IHC (FS), IHC (PS)

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage