This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
Toxin A (Clostridium difficile)
catalog :
ALX-630-100-C100
quantity :
100 µg
citations: 7
Reference
Jank T, Giesemann T, Aktories K. Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. Glycobiology. 2007;17:15R-22R pubmed
Voth D, Ballard J. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev. 2005;18:247-63 pubmed
Schirmer J, Aktories K. Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins. Biochim Biophys Acta. 2004;1673:66-74 pubmed
Pothoulakis C. Effects of Clostridium difficile toxins on epithelial cell barrier. Ann N Y Acad Sci. 2000;915:347-56 pubmed
Fiorentini C, Thelestam M. Clostridium difficile toxin A and its effects on cells. Toxicon. 1991;29:543-67 pubmed
Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54 pubmed
Rolfe R, Finegold S. Purification and characterization of Clostridium difficile toxin. Infect Immun. 1979;25:191-201 pubmed
product information
Product ID :
ALX-630-100
Catalog Number :
ALX-630-100-C100
Product Name :
Toxin A (Clostridium difficile)
Product Type :
Protein
Size :
100 µg
list of Pubmed id :
17237138, 15831824, 15238250, 11193598, 1926159, 942051 , 478634
Product Description :
Has potent cytotoxic and enterotoxic properties. Translocates to the cytosol of target cells and glucosylates small GTP-binding proteins such as Rho, Rac, and Cdc42. Induces actin condensation, cell death and opening of the tight junctions. Triggers release of pro-inflammatory cytokines from intestinal epithelial cells probably via activation of MAP kinases.
Buffer :
Lyophilized from 50mM TRIS, pH 7.5, containing 50mM sodium chloride and 0.1% trehalose.
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.